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Perfect 12-team, Pick 2 2025 fantasy football draft strategy, round by round

  • Bijan Robinson dominated late last season: Robinson’s role increased substantially over the second half of last season, leading to an elite 22.4 PPR points per game over the previous nine games.
  • Trey McBride provides another safe floor: The Arizona Cardinals similarly kept their offense nearly identical to last season, making McBride the safest tight end option in the draft.
  • Data, tools and expert insights: Use code earlybird to save $20 on your PFF+ annual subscription.

Estimated reading time: 13 minutes


This perfect draft strategy for 12-team, single-quarterback, redraft, PPR fantasy football leagues uses a consensus of current average draft positions (ADPs) from ESPN, Sleeper and Yahoo! to deliver a round-by-round guide for managers picking second overall. To find more information about any player mentioned in this article, click on the player's name to find their fantasy football player profile.

Last updated: Wednesday, August 13


Round 1, Pick 2: Draft a running back

Ja’Marr Chase has the highest ADP at ESPN, Sleeper, and Yahoo!, which means he is the only player likely to be off the board at this point. There is some level of risk to every other wide receiver on the board, as Justin Jefferson is playing with a new quarterback and CeeDee Lamb is coming back from injury with a quarterback who is also coming back from injury and wasn’t playing well last season before the injury. This means that picking the top running back is the best option, and Bijan Robinson is the top available running back. If a running back is selected first overall, it’s fine to pivot to Chase and then switch from wide receiver to running back with a different early pick.

Top Target: Bijan Robinson

Bijan Robinson was a rare top-10 NFL draft pick at running back, leading to hefty expectations. He began meeting those expectations over the second half of 2024, consistently playing over 70% of the Falcons' offensive snaps and running at least 17 times in all but one game. This led to 22.4 fantasy points per game over the last nine weeks. He didn’t see as many 15-plus-yard carries as other great running backs, even though he’s got the talent and speed to have those runs. It’s possible some positive regression could greatly help his fantasy production this season. He lost Drew Dalman at center and still has an elite backup in Tyler Allgeier, so there is also some room to lose fantasy value.

Possible Targets: Jahmyr Gibbs, Saquon Barkley, Christian McCaffrey, Ashton Jeanty, Bucky Irving


Round 2, Pick 23: Draft a tight end

It is generally helpful to select a tight end early or a quarterback early. This allows you only to pick one player at those positions and place them in your lineup each week. That gives you more roster flexibility to add additional high upside options at running back and wide receiver, increasing your odds of selecting this year’s breakout star. We can be more confident in the late-round quarterbacks this season relative to the tight ends, and it can also be easier to select which quarterback to start each week based on matchups. The best way to ensure you can get a top-three tight end at a decent value is with Trey McBride at this pick, as Brock Bowers is likely off the board, and if McBride is gone by Round 3, it will be a little early for George Kittle.

Top Target: Trey McBride

McBride became the Cardinals' primary tight end in the middle of the 2023 season, and he’s been an elite fantasy option at the position ever since. He averaged at least 15 PPR points in both seasons once he became the starter. McBride led the league in both receptions per game (6.9) and receptions per route (0.21) last season. His yards per game (71.6) and targets per game (8.7) were both second-best. The Cardinals kept the coaching staff and players on the offense essentially the same as last season, making it easier to expect more of the same from McBride. If anything, we can expect a few more touchdowns after his low touchdown total from last season.

Possible Targets: George Kittle, T.J. Hockenson, Sam LaPorta, David Njoku, Tucker Kraft

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