Colorado State quarterback Hauss Hejny, Memphis tight end Hunter Tipton and LSU linebacker TJ Dottery headline PFF’s college football Team of the Week after delivering three of the standout individual performances of Week 2.

Fantasy football Week 1 waiver wire targets include Michael Mayer, Tyler Shough and several running backs with paths to increased opportunities. Mayer enters the opener as Las Vegas’ lead tight end, while Shough offers a widely available quarterback option against Detroit. The PFF Waiver Wire Tool helps fantasy managers identify available players based on league settings, roster percentage and matchups.

NFL same-game parlay picks for Week 1 feature data-backed betting angles for the Buccaneers, Raiders and Texans. Cade Otton, Kirk Cousins and Jaylin Noel headline SGP builds based on coverage weaknesses, passing volume and matchup advantages. PFF Advanced Stats and the PFF Player Prop Tool help identify the data behind each correlated bet.

The Jets-Titans Week 1 matchup presents betting opportunities based on protection, disruption pressure and coverage. Geno Smith faces a Tennessee defense that struggled to create disruption last season, while Cam Ward draws a Jets defense that plays heavy man coverage. PFF Advanced Stats point to New York as a potential value against a Titans team favored at home.

NFL anytime touchdown picks for Week 1 feature Javonte Williams, Saquon Barkley and Dalton Kincaid in favorable scoring situations. Williams and Barkley draw defenses that struggled against the run last season, while Kincaid faces a zone-heavy Houston defense. PFF Advanced Stats and Tools help identify the matchup and usage data behind each touchdown bet.

NFL Week 1 betting opportunities emerge from PFF data on disruption pressure and perfect coverage. Cooper Rush faces a Pittsburgh Steelers pass rush that can attack one of his historical weaknesses, while C.J. Stroud draws a rebuilt Buffalo Bills secondary.

The San Francisco 49ers cruised past the Los Angeles Rams 27–7 in Week 1 on September 11, 2026. 49ers outgained the Rams, 379 total yards to 290.

The San Francisco 49ers defeated the Los Angeles Rams 27-7 in the NFL’s first game in Australia. San Francisco found success through the air and on the ground, while several high-leverage plays went against Los Angeles. PFF Advanced Stats break down the passing, receiving, rushing and efficiency performances from the 2026 season opener.

Veterans Mike Evans and Deebo Samuel answered questions right off the bat to galvanize the 49ers' big victory over the rival Rams in Australia.

The best fantasy football offensive environments combine efficient play calling with schemes that can concentrate touches among established starters. Play action and motion produced efficiency gains across the NFL in 2025, while heavier personnel packages reduced the number of wide receivers on the field. The Rams, Bears, Chargers and several other offenses stand out entering the 2026 fantasy football season.

Raiders receiver Tre Tucker and Chargers receiver Quentin Johnston could be positioned for big outputs in Week 1, making them candidates to occupy fantasy managers' flex slots.

Tampa Bay Buccaneers receiver Chris Godwin and Jacksonville Jaguars wideout Parker Washington could be poised to take advantage of prime coverage opportunities in Week 1.

The Philadelphia Eagles and Los Angeles Chargers could exploit weak run defenses in Week 1, setting up their running backs and quarterbacks for fantasy success.

The Pittsburgh Steelers and Las Vegas Raiders profile as two offenses that could thrive through the air in Week 1 against weaker Falcons and Dolphins defenses, respectively.

The fantasy football Week 1 recap breaks down major usage developments from the San Francisco 49ers and Los Angeles Rams. Kaelon Black cut into Christian McCaffrey’s workload, while De’Zhaun Stribling earned a prominent role before suffering an ankle injury. The Rams also adjusted their running back and tight end rotations, creating new fantasy considerations for Kyren Williams and Terrance Ferguson.

Devon Witherspoon’s role with the Seattle Seahawks extends well beyond his cornerback designation. After lining up across five different alignments in 2025, Witherspoon worked from the slot, outside cornerback, the box and defensive line in the 2026 opener. His expanding pass-rushing workload adds another dimension after he earned a 90.1 PFF overall grade last season.

Christian Gonzalez opened the 2026 season with an 87.4 PFF grade in the New England Patriots’ loss to the Seattle Seahawks. Gonzalez allowed one catch for 4 yards on five targets and earned an 86.3 PFF coverage grade.

PFF Premium Stats Pro breaks down Drake Maye’s performance in the New England Patriots’ 13-10 Week 1 loss to the Seattle Seahawks. Maye earned a 28.4 PFF passing grade under pressure after posting a 24.4 mark in the Super Bowl matchup. PFF Grades and Advanced Stats show how Seattle’s pressure continued to disrupt the Patriots quarterback.