Jameis Winston opens up the New Orleans Saints' playbook for more high-variance plays, and it worked to perfection in Week 1 against the Green Bay Packers.

Matthew Stafford made his debut for the Los Angeles Rams after moving from Detroit, while Chicago Bears rookie Justin Fields made his first appearance with his franchise, even if he was only holding the clipboard. In the end, the game ended how most expected — with Stafford’s Rams cruising to a 34-14 win.

Aaron Rodgers fell flat while Jameis Winston thrived, allowing the New Orleans Saints to run away with a 38-3 win over the Green Bay Packers in Week 1 of the 2021 NFL season.

The Kansas City Chiefs began their AFC title defense with a 33-29 come-from-behind victory over the Cleveland Browns in Week 1 of the 2021 NFL season.

Marshon Lattimore, a 2017 first-round draft pick, is now the second-highest-paid cornerback in the NFL after signing an extension with the New Orleans Saints.

Mac Jones nearly led the New England Patriots to a comeback win, but a late Patriots fumble preserved the 17-16 victory for Tua Tagovailoa and the Miami Dolphins in Week 1 of the 2021 NFL season.

Teddy Bridgewater silenced his critics in Week 1 with a solid showing against the New York Giants, leading the Denver Broncos to a 27-13 win in Week 1 of the 2021 NFL season.

The  Arizona Cardinals dominated the Tennessee Titans 38-13  during Week 1 of the NFL season.

The San Francisco 49ers held on for a 41-33 win over the Detroit Lions despite watching their 28-point lead reduced to just 8 during the game’s final minutes.

The Carolina Panthers suffocated a young New York Jets team in the Sam Darnold Revenge Game, scoring just enough to get the 19-14 win.

Jalen Hurts had a career day and rookie receiver Devonta Smith caught his first career touchdown pass as the Philadelphia Eagles routed the Atlanta Falcons, 32-6, during Week 1 of the 2021 NFL season.

While the Minnesota Vikings forced overtime with a late field goal, quarterback Joe Burrow was triumphant in his return from a serious knee injury as the Bengals hung on for a 27-24 win in Week 1 of the 2021 NFL season.

Seattle Seahawks quarterback Russell Wilson carved up the Indianapolis Colts defense like a hot knife en route to a 28-16 Week 1 win.

The Houston Texans took a 20-point lead into halftime and cruised to a 37-21 victory over the Jacksonville Jaguars, spoiling Trevor Lawrence's debut in Week 1 of the 2021 NFL season.

The Pittsburgh Steelers pulled off a surprise win over Josh Allen and the Buffalo Bills in Week 1 of the 2021 NFL season.

A late fumble from running back Antonio Gibson gave new life to the Los Angeles Chargers, who eked out a 20-16 win over the Washington Football Team in Week 1 of the 2021 NFL season.

Per ESPN’s Adam Schefter, the San Francisco 49ers traded up to No. 3 overall in the 2021 NFL Draft partly in fear that the New England Patriots would trade up for quarterback Mac Jones.

Get all the betting information you need for Sunday night's Los Angeles Rams-Chicago Bears contest.