The Packers staked control of the NFC North with a competitive victory over the Bears. Christian Watson racked up 89 receiving yards and two more touchdowns, and Keisean Nixon intercepted Caleb Williams on fourth down to seal the victory.

The Rams steamrolled the Cardinals 45-17 behind a near-flawless offensive performance that piled up more than 500 yards, with Matthew Stafford throwing three touchdowns and playmakers Puka Nacua, Blake Corum, and Kyren Williams all erupting for big scoring days.

The Broncos won another game by one score, defeating the Raiders 24-17 to move to 11-2. Bo Nix completed 31-of-38 attempts for 212 yards, and the Denver's offense nearly doubled Las Vegas' time of possession.

Tony Pollard exploded for a career-best 161 rushing yards and two touchdowns, and Tennessee’s defense delivered three second-half takeaways as the Titans survived Shedeur Sanders’ late rally to beat the Browns 31-29 in snowy Cleveland.

Aaron Rodgers was at his best, and the Ravens' mistakes cost them again, helping the Steelers move into first place in the AFC North.

Rookie QB Tyler Shough powered the Saints past the Buccaneers, rushing for touchdowns of 34 yards and 13 yards in a 24–20 win that snapped New Orleans’ two-game skid.

The Jaguars claimed sole possession of the AFC South, but the bigger storyline of the game was quarterback Daniel Jones' likely season-ending Achilles injury.

The Dolphins jumped out to an early and never looked back. For the Jets, starting quarterback Tyrod Taylor exited with an injury and gave way to rookie Brady Cook.

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The Bills overcame a 28-18 fourth-quarter deficit via two interceptions and Josh Allen's legs, securing their ninth win of the season.

Seattle blew open a 6–6 game at halftime with a 31-point second-half avalanche, highlighted by Rashid Shaheed’s 100-yard kickoff-return touchdown and three takeaways from a fully healthy Seahawks defense in a 37–9 rout of Atlanta.

The injury-riddled Commanders dropped their eighth straight game in a 31–0 blowout loss to the Vikings, falling to 3–10 in their most lopsided defeat of the season. Jayden Daniels returned from a dislocated elbow only to exit again in the third quarter after reinjuring the same arm on a hit following an interception, leaving Washington without its starter as the offense and defense both sputtered.

Indiana's Fernando Mendoza and Texas Tech linebacker Ben Roberts headline the PFF College Football Team of the Week.

Chiefs quarterback Patrick Mahomes may find it difficult to escape pressure from the Texans' pass rush with three of his starting offensive line set to miss the game.

Cleveland’s defensive dominance sets up a game script where the Browns can flood the Titans with play volume, creating strong correlated value on their offensive props. Meanwhile, Patrick Mahomes’ ability to mitigate Houston’s pressure makes Xavier Worthy a prime beneficiary against a Texans defense vulnerable to deep shots out of single-high looks.

Caleb Williams’ ability to extend plays and avoid sacks directly counters a Packers defense that relies on quick pressure and top-10 sack conversion to win. Paired with Chicago’s dominant run game, that advantage gives the Bears a stable floor to score points and exploit a Green Bay defense that appears overrated in its current form.

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James Cook, Breece Hall and Alec Pierce all draw premium matchups this week, with Cook facing a Bengals defense bleeding production to running backs, Hall taking on a Miami unit vulnerable to backs in the passing game and Pierce matching up with a Jaguars secondary that struggles against outside receivers.