Trevor Lawrence threw three touchdown passes to set the Jaguars’ single-season scoring record as Jacksonville clinched the AFC South and a home playoff game with a 41-7 rout of Tennessee. The win capped a dominant division run for the Jaguars, while the Titans were overwhelmed and lost rookie quarterback Cam Ward to a shoulder injury early.

PFF’s media research team has been hard at work this week, preparing for kickoff by pulling data-driven insights and talking points for our broadcast partners around the league. Now, we’re sharing those same nuggets with you. So, whether you’re looking to win your fantasy matchup, hit on your bets or just get smarter about the game, these are the key storylines to know for every Week 18 contest.

We get playoff football a little early in Pittsburgh, with this matchup the only true win-and-in game of the weekend. 

With 256 games already in the books from Weeks 1 through 17, the sheer volume of plays this season provides a robust sample size for meaningful trends to emerge. In this article, we’ll dive into five of the most interesting statistical stories that data has revealed.

Seattle locked up the NFC’s No. 1 seed and the NFC West title by stifling San Francisco’s high-powered offense in a 13-3 win, leaning on a dominant defense and a balanced run game. The loss sends the 49ers on the road for the wild-card round after their lowest-scoring and lowest-yardage outing under Kyle Shanahan.

Baker Mayfield threw a touchdown to Cade Otton and Chase McLaughlin kicked three field goals as the Buccaneers stayed alive with a sloppy 16-14 win over the Panthers in rainy Tampa. Tampa Bay now needs New Orleans to beat or tie Atlanta to clinch the NFC South, while Carolina can still win the division if the Falcons prevail.

The regular season finale is here, and PFF’s analysts have locked in their favorite bets of the week, powered by the PFF Player Prop Tool.

Watson missed half of the 2025 season, but his 17-game pace is that of a top-tier fantasy receiver. Williams continues to showcase unparalleled explosiveness, flashing an ability to excel without significant target volume.

Dynasty fantasy football values can shift in the blink of an eye. Some players fail to make good on their projections, while others come out of nowhere to propel your roster.

Utilizing the new PFF Player Prop Tool, here are two projections to target ahead of NFL Week 18 action.

Below are 10 head-to-head collisions to circle as you determine which games to prioritize watching and/or following this weekend, including Alex Highsmith vs. Ronnie Stanley.

The Browns boast the NFL’s best defensive line in 2025, anchored by Defensive Player of the Year favorite Myles Garrett, who leads the league with a 92.7 overall grade while ranking among the top edge defenders against both the run and the pass. Even after losing Maliek Collins to injury, Cleveland’s depth — highlighted by Alex Wright, Isaiah McGuire and a surging rookie Mason Graham — has kept the unit dominant from top to bottom.

Ole Miss continued its remarkable postseason surge, edging Georgia 39-34 in a thrilling College Football Playoff quarterfinal at the Sugar Bowl, proving the Rebels haven’t missed a beat since Lane Kiffin’s departure.

Behind three touchdown passes from Heisman winner Fernando Mendoza and a dominant performance in the trenches, the top-seeded Indiana Hoosiers (14-0) controlled the game from start to finish. Indiana jumped out to a 24-0 lead, outgained Alabama 407–193, and suffocated the Crimson Tide offense, holding them scoreless until a third-quarter field goal.

Cooper DeJean continues to separate himself at the top of the coverage metrics, pairing a league-leading advanced coverage grade with elite playmaking production, including 18 pass stops and 12 forced incompletions. Meanwhile, Jamel Dean remains the model of consistency, allowing a catch on just 45.5% of targets with a 46.9 passer rating allowed.

Oregon dominated Texas Tech 23-0 in the College Football Playoff quarterfinal at the Orange Bowl, forcing four sacks and two interceptions while holding the Red Raiders to nine first downs. Dante Moore played efficiently and Jordan Davison scored twice as the Ducks advanced to the CFP semifinals, handing Texas Tech just the third shutout loss in playoff history.

PFF is grading every player on every play during the 2025 NFL season, and these are the top wide receivers by PFF receiving grade through 17 weeks.

Gain a fantasy football edge in Week 18 by targeting or avoiding these wide receivers based on their cornerback matchups.