Week Two concludes with a Monday-night doubleheader beginning with the Titans visiting the Bills, followed by the Eagles hosting the Vikings. Below are lines courtesy of BetMGM and PFF's best bets.
Check back for more bets early Monday.
Estimated reading time: 3 min
Monday, Sept. 19
Tennessee Titans @ Buffalo Bills
| Spread | Total | Moneyline | |
| Titans | +10 (-110) | O47.5 (-110) | +350 |
| Bills | -10 (-110) | U47.5 (-110) | -450 |
· Best SGP: Stefon Diggs TD, Dawson Knox TD, Josh Allen 275+ pass yards, Derrick Henry U 87.5 rush yards: Buffalo poised to steamroll again on offense.
Minnesota Vikings @ Philadelphia Eagles
| Spread | Total | Moneyline | |
| Vikings | +2.5 (-110) | O50.5 (-110) | +115 |
| Eagles | -2.5 (+110) | U50.5 (-110) | -140 |
· Best SGP: Justin Jefferson 100 rec. yards and a TD, Kirk Cousins 300+ pass yards, MIN -5.5: Vikes continue scheming Jefferson open en route to win.
Sunday, Sept. 18
Miami Dolphins @ Baltimore Ravens
| Spread | Total | Moneyline | |
| Dolphins | +3.5 (-110) | O 44 (-110) | +155 |
| Ravens | -3.5 (-110) | U 44 (-110) | -190 |
• BET Dolphins TE Durham Smythe O 10.5 RECEIVING YARDS (-113 FD): Played 100% of the time in all two-TE sets, including 75% in 21 personnel/29% in 11; Bal allowed third-most yards to TEs in 2021.
New York Jets @ Cleveland Browns
| Spread | Total | Moneyline | |
| Jets | +6.5 (-110) | O 38.5 (-110) | +225 |
| Browns | -6.5 (-110) | U 38.5 (-110) | -275 |
• BET Jets-Browns O 38.5 (-110 BetMGM): Cleveland's True Score was 25.2 in Week 1; Jets top positive regression candidate (Week 1 True Score of 24.6).
• BET Elijah Moore U 50.5 receiving yards (-110 PointsBet): The Jets will likely struggle against the Browns' pass rush, plus Cleveland is set to burn clock with a ground-heavy attack.
Washington Commanders @ Detroit Lions
| Spread | Total | Moneyline | |
| Commanders | -1 (-110) | O 48 (-110) | -110 |
| Lions | +1 (-110) | U 48 (-110) | -110 |
• BET Commanders RB Antonio Gibson anytime TD (-105 DraftKings): Only Texans & Jets have allowed more rush TDs than Lions (23) since start of 2021.
• BET Commanders WR Terry McLaurin anytime TD (+165 FD): Playing Washington's most passing-down snaps in Week 1, McLaurin will build on 2-58-1 rec. as Wentz targets increase.
Indianapolis Colts @ Jacksonville Jaguars
| Spread | Total | Moneyline | |
| Colts | -3 (-110) | O 43.5 (-110) | -165 |
| Jaguars | +3 (-110) | U 43.5 (-110) | +140 |
• BET RB Jonathan Taylor — Over 100.5 Rus Yards (-110 PointsBet): Since the start of the 2020 season, Taylor has racked up 292 total rushing yards over expected.
Tampa Bay Buccaneers @ New Orleans Saints
| Spread | Total | Moneyline | |
| Buccaneers | -2.5 (-110) | O 43.5 (-110) | -145 |
| Saints | +2.5 (-110) | U 43.5 (-110) | +120 |
• BET: Saints U 20.5 total points (+100 DraftKings): Saints are negative regression candidate in part because Bucs ‘D' posted NFL-best 3.9 True Score at Dallas in Week 1.
• BET Bucs -2.5: Tampa Bay the clear top team in the NFC South and should end its losing ways against New Orleans
Carolina Panthers @ New York Giants
| Spread | Total | Moneyline | |
| Panthers | -1 (-110) | O 43.5 (-110) | -115 |
| Giants | +1 (-110) | U 43.5 (-110) | -105 |
• BET QB Baker Mayfield O 1.5 pass TDs (+150 BetMGM): Carolina offense is a clear mismatch for a Giants secondary lacking high-end starters (NFL-worst coverage grade Week 1).
New England Patriots @ Pittsburgh Steelers
| Spread | Total | Moneyline | |
| Patriots | -3 (+100) | O40 (-110) | -155 |
| Steelers | +3 (-120) | U40 (-110) | +125 |
BET Steelers +3: Feel comfortable with a small wager on the Steelers as home dogs, but be cautious in the interpretation that this line has six points of value.
Atlanta Falcons @ Los Angeles Rams
| Spread | Total | Moneyline | |
| Falcons | +10 (-110) | O46(-115) | +375 |
| Rams | -10 (-110) | U46(-105) | -500 |
• BET: Rams WR Allen Robinson anytime TD, FIRST TD (+130, +750 DK): A-Rob was on field Week 1 for 49 passing play snaps, running a route on 48; Falcons CBs graded in 50s.
• BET Falcons K Younghoe Koo O 1.5 FGs made (+100 Betonline): He's hit over 1.5 FGM in his past 6 games and will be kicking in a dome on Sunday.
Seattle Seahawks @ San Francisco 49ers
| Spread | Total | Moneyline | |
| Seahawks | +9 (-110) | O39.5 (-110) | +325 |
| 49ers | -9 (-110) | U39.5 (-110) | -450 |
• BET RB Jeff Wilson O 8.5 rec yards (-120 DK): Seattle's 1125 receiving yards allowed to backs since 2021 is NFL high.
• BET TE Noah Fant U 2.5 receptions (+125 BetMGM): The Seattle Seahawks have used a three-man rotation at tight end, making it hard to trust any of them to see enough receiving production.
Cincinnati Bengals @ Dallas Cowboys
| Spread | Total | Moneyline | |
| Bengals | -7 (-115) | O41.5 (-110) | -350 |
| Cowboys | +7 (-105) | U41.5 (-110) | +275 |
BET Cowboys +7.5 (-114 FD): Nine points of line movement is unjustifiable. With market overreacting to Dak Prescott’s absence, and excusing the Bengals’ own troubles, this is a terrific opportunity to back Dallas at home.
Houston Texans @ Denver Broncos
| Spread | Total | Moneyline | |
| Texans | +10 (-110) | O45.5 (-110) | +375 |
| Broncos | -10 (-110) | U45.5 (-110) | -500 |
• BET Broncos O 28.5 (-105 DraftKings): True Score of 26.3 nearly 10 more than actual because of fumbling and clock management.
Arizona Cardinals @ Las Vegas Raiders
| Spread | Total | Moneyline | |
| Cardinals | +5.5 (-110) | O51.5 (-110) | +180 |
| Raiders | -5.5 (-110) | U51.5 (-110) | -225 |
• BET Cardinals alt lines (-2.5/-5.5): This line moved from Arizona +3.5-to-Arizona+5.5 — take the other side.
Chicago Bears @ Green Bay Packers
| Spread | Total | Moneyline | |
| Bears | +10 (-110) | O41.5 (-110) | +375 |
| Packers | -10 (-110) | U41.5 (-110) | -500 |
• BET Packers -10: GB has 21-7 ATS mark against Bears in Aaron Rodgers era, 7-1 ATS at Lambeau last season (avg. win margin 6).
Thursday, Sept. 15
Los Angeles Chargers @ Kansas City Chiefs
| Spread | Total | Moneyline | |
| Chargers | +4.5 (-110) | O 54 (-110) | +170 |
| Chiefs | -4.5 (-110) | U 54 (-110 | -200 |
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