The Los Angeles Chargers got out to a 27-7 first-half lead and held on through the second half to beat the rallying Houston Texans 23-24 in Week 4.

Offensive spotlight: Chargers RB Austin Ekeler racked up 60 rushing yards and two rushing scores on 13 carries and added 49 receiving yards and a receiving touchdown through the air. He averaged 2.1 yards after contact per rush attempt, forced three missed tackles and generated a 135.4 passer rating as a receiver.
Defensive spotlight: Derwin James was a nightmare for receivers in this one. Targeted six times in coverage, he gave up just three catches for three receiving yards and forced two incompletions, too.
Rookie spotlight: Texans cornerback Derek Stingley Jr. was targeted nine times in coverage, and he gave up seven catches for 72 yards and four first downs.
Offensive line spotlight: Chargers rookie tackle Jamaree Salyer kept a completely clean slate in pass protection on first review and will likely end up with an 80.0-plus pass-blocking grade.
Box Score
Passing
| Los Angeles Chargers | |||||||
| Player | Fantasy | Comp/Att | Yds | YPA | TD | Int | Rtg |
| Justin Herbert | 24.1 | 27 / 39 | 340 | 8.7 | 2 | 0 | 113.2 |
| Houston Texans | |||||||
| Player | Fantasy | Comp/Att | Yds | YPA | TD | Int | Rtg |
| Davis Mills | 15.8 | 26 / 35 | 246 | 7.0 | 2 | 2 | 88.5 |
Rushing
| Los Angeles Chargers | |||||||
| Player | Fantasy | Car | Yds | YPC | TD | Long | Fum Lost |
| Austin Ekeler | 34.9 | 13 | 60 | 4.6 | 2 | 20 | 0 |
| Justin Herbert | 24.1 | 4 | -5 | -1.2 | 0 | -1 | 0 |
| Sony Michel | 5.7 | 6 | 11 | 1.8 | 0 | 4 | 0 |
| Joshua Kelley | 1.5 | 4 | 15 | 3.8 | 0 | 6 | 0 |
| Houston Texans | |||||||
| Player | Fantasy | Car | Yds | YPC | TD | Long | Fum Lost |
| Dameon Pierce | 28.9 | 14 | 131 | 9.4 | 1 | 75 | 0 |
Receiving
| Los Angeles Chargers | |||||||
| Player | Fantasy | Tgt | Rec | Yds | YPT | TD | Long |
| Austin Ekeler | 34.9 | 7 | 6 | 49 | 7.0 | 1 | 21 |
| Mike Williams | 22.0 | 11 | 7 | 120 | 10.9 | 0 | 50 |
| Gerald Everett | 17.1 | 6 | 5 | 61 | 10.2 | 1 | 18 |
| Michael Bandy | 6.9 | 2 | 2 | 49 | 24.5 | 0 | 25 |
| Sony Michel | 5.7 | 3 | 3 | 16 | 5.3 | 0 | 9 |
| Joshua Palmer | 3.5 | 1 | 1 | 25 | 25 | 0 | 25 |
| DeAndre Carter | 2.6 | 3 | 2 | 16 | 5.3 | 0 | 14 |
| Joshua Kelley | 1.5 | 2 | 0 | 0 | 0.0 | 0 | 0 |
| Tre' McKitty | 1.4 | 1 | 1 | 4 | 4.0 | 0 | 4 |
| Zander Horvath | 0.0 | 1 | 0 | 0 | 0.0 | 0 | 0 |
| Houston Texans | |||||||
| Player | Fantasy | Tgt | Rec | Yds | YPT | TD | Long |
| Dameon Pierce | 28.9 | 6 | 6 | 8 | 1.3 | 0 | 8 |
| Brandin Cooks | 18.7 | 7 | 7 | 57 | 8.1 | 1 | 20 |
| Rex Burkhead | 14.9 | 5 | 5 | 39 | 7.8 | 1 | 13 |
| Nico Collins | 11.2 | 5 | 3 | 82 | 16.4 | 0 | 58 |
| Jordan Akins | 5.3 | 2 | 2 | 33 | 16.5 | 0 | 30 |
| O.J. Howard | 4.7 | 5 | 2 | 27 | 5.4 | 0 | 22 |
| Mason Schreck | 1.0 | 1 | 1 | 0 | 0.0 | 0 | 0 |
| Phillip Dorsett | 0.0 | 2 | 0 | 0 | 0.0 | 0 | 0 |
| Chris Moore | 0.0 | 2 | 0 | 0 | 0.0 | 0 | 0 |