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NFL Week 2 Betting: Best early spread bets before lines move

2Y20FT2 Indianapolis Colts quarterback Anthony Richardson (5) during the first half of an NFL football game against the Houston Texans, Sunday, Sept. 8, 2024, in Indianapolis. (AP Photo/Darron Cummings)

• Take the Colts (-3) against a weakened Packers offense: Green Bay is expected to be without injured quarterback Jordan Love, yet Indianapolis remains just a three-point favorite.

• The Saints (+7) present good value in a matchup with the Cowboys: New Orleans proved in Week 1 that it might be a very underrated team, one capable of hanging with the NFC's top-tier squads.

• Dominate your fantasy draft: Subscribe to PFF+ to get full access to PFF’s suite of fantasy football tools, including the fantasy mock draft simulator, live draft assistant, fantasy draft rankings, cheat sheets and more! Click here to subscribe!

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NFL Week 1 is nearly a wrap, and betting lines are now available for Week 2. Here are our favorite early spread picks for the slate.

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