Shedeur Sanders made his NFL debut after Dillon Gabriel's concussion, but the Ravens eked out the comeback win.

In a game between two of the NFL's best teams, Los Angeles' defense proved the difference. The Rams haunted Sam Darnold to the tune of four interceptions despite a quiet day from Matthew Stafford. Jason Myers' potential game-winning 61-yard field goal missed wide right, moving the Rams to 8-2.

Brock Purdy's return went swimmingly for the 49ers, as the quarterback threw for 220 yards and three touchdowns in a dominant win over the Cardinals. Christian McCaffrey tacked on 121 yards and total three touchdowns in a big day for San Francisco's offense, which offset a historic 452-yard afternoon for Jacoby Brissett.

Bryce Young threw a late touchdown to Tet McMillan and Carolina sealed it in overtime to beat the Atlanta Falcons 30-27, completing a season sweep and handing Atlanta its fifth straight loss. The Falcons built a 21-7 lead behind three rushing touchdowns from Bijan Robinson and Tyler Allgeier, but a series of turnovers, coverage busts and special teams miscues — including a fumbled kickoff and multiple big gains allowed through the air — let the Panthers claw back

Davis Mills hit Nico Collins for a key third-and-16 conversion to set up Matthew Wright’s 35-yard field goal as time expired, lifting the Houston Texans past the Tennessee Titans 16-13 in Week 11.

Josh Allen brushed off some early mistakes and accounted for six touchdowns in the Bills' Week 11 win over the Buccaneers.

Two defensive touchdowns propelled the Steelers to an eventual blowout win of the Bengals in Week 11.

Jordan Love returned from a shoulder injury to throw two touchdown passes, including a go-ahead strike to Christian Watson in the fourth quarter, as the Green Bay Packers edged the New York Giants 27-20. Backup Malik Willis added a rushing score while filling in briefly, and Emanuel Wilson ran for a touchdown and caught the two-point conversion that followed Watson’s late TD. Evan Williams sealed the win with an end-zone interception of Jameis Winston, helping Green Bay snap a two-game skid and move to 6-3-1 despite losing Josh Jacobs to a knee injury.

The Bears nullified a late Vikings touchdown with a game-winning field goal following Devin Duvernay's 56-yard kickoff return.

Travis Etienne, Trevor Lawrence and rookie Bhaysul Tuten each scored on the ground as the Jacksonville Jaguars rolled past the Los Angeles Chargers 35-6. Jacksonville controlled the game from the start, holding the Chargers to just 135 total yards and eight first downs while intercepting Justin Herbert and sacking him twice before he was replaced in the fourth quarter

De’Von Achane powered Miami’s run game for 119 yards, and Jack Jones’ overtime interception set up Riley Patterson’s winning field goal as the Dolphins edged the Washington Commanders 16-13 in Madrid.

The New England Patriots remain on pace for their first division title since 2019 after edging the New York Jets 27-14 on Thursday night.

Below are 10 head-to-head collisions to circle as you determine which games to prioritize watching and/or following this weekend, including Amon-Ra St. Brown vs. Cooper DeJean.

Justin Jefferson draws a highly favorable matchup against a struggling Chicago secondary, making his 69.5-yard receiving line appealing given his consistent target volume. Josh Jacobs also profiles well to clear 78.5 rushing yards as Green Bay leans on him against a Giants defense that ranks near the bottom of the league in run-defense grade.

Drake Maye delivered another efficient performance and TreVeyon Henderson scored three touchdowns as the New England Patriots pulled away from the New York Jets for a 27-14 win on Thursday night.

At PFF, the run game matters just as much as the pass game, and every play is meticulously graded. Each week, we’ll be looking at the highest-graded run blockers and run defenders from each position.

PFF’s media research team has been hard at work this week, preparing for kickoff — pulling data-driven insights and talking points for our broadcast partners around the league. Now, we’re sharing those same nuggets with you. So, whether you’re looking to win your fantasy matchup, hit on your bets or just get smarter about the game, these are the key storylines to know for every Week 11 contest.

We're diving into the top wide receivers by PFF receiving grade through Week 10 of the 2025 NFL season. To qualify, players need to have played at least 100 receiving snaps. For even more information, including snap counts, receiving by depth, per-route data and more, subscribe to PFF+.