From running back depth chart observations to concerning tight end usage, here are the 10 biggest fantasy football takeaways from Week 2 of the 2021 NFL preseason.

Breaking down the ideal round-by-round strategy for 2021 PPR fantasy football drafts.

Identifying the 2021 season's top fantasy players by best ball ADP at Underdog Fantasy and comparing their relative positional value versus our half-PPR projections. Green Bay's Aaron Jones stands out as a value, as does Raiders back Kenyan Drake.

A bevy of top college football coaches are on the seat entering the 2021 season, including Michigan's Jim Harbaugh and USC's Clay Helton, and their teams might be worth fading.

The San Francisco 49ers defeated the Los Angeles Chargers 15-10 in a game where the main focus was on the QB1 battle between Jimmy Garoppolo and Trey Lance.

Neither the Cleveland Browns nor the New York Giants played many regular starters in what turned into a thrilling 17-13 Browns win in Week 2 of the 2021 NFL preseason.

The Cleveland Browns boast a dangerous offense led by quarterback Baker Mayfield that should support multiple relevant skill players, from running back Nick Chubb to wide receiver Odell Beckham, Jr., for 2021 fantasy football.

Cincinnati Bengals quarterback Joe Burrow returns to lead an offense stocked with skill players worth targeting in 2021 fantasy football leagues.

Neither team played many of its starters, but the Raiders won a surprisingly exciting 17-16 game that became a last-second nail-biter.

The Baltimore Ravens stifled the Carolina Panthers with stout defense and a bruising run game in Week 2 of the 2021 NFL preseason.

The Indianapolis Colts rode their kicking game to victory Saturday night, defeating the Minnesota Vikings 12-10 behind four field goals.

On the back of three interceptions from Dallas Cowboys backup quarterback Ben Dinucci, the Houston Texans escaped Saturday with a 20-14 victory.

Ben Roethlisberger found rookie tight end Pat Freiermuth for two touchdowns in the Pittsburgh Steelers preseason Week 2 win over the Detroit Lions.

In a game where both teams rested most of its starters, the Tennessee Titans came away with a dominant 34-3 victory over the Tampa Bay Buccaneers.

Second-year Dolphins quarterback Tua Tagovailoa looked comfortable in his preseason Week 2 action against the Atlanta Falcons, and Myles Gaskin was the clear lead back for Miami.

In a game where most of the Seattle Seahawks' starters were resting, the Denver Broncos easily bested them 30-3.

Rookie quarterback Zach Wilson shined in limited action against the Green Bay Packers, further building up the hype around him ahead of the 2021 NFL season.

Mitchell Trubisky got some revenge against his former team on Saturday, leading the Buffalo Bills to four consecutive touchdown drives to open up the game en route to a 41-15 win over the Chicago Bears that was never in question.