The Jacksonville Jaguars shut out the Indianapolis Colts, 24-0, in Week 2 behind a ferocious defensive effort that included five sacks and three interceptions.

Offensive spotlight: Jaguars wide receiver Christian Kirk caught all six of his targets for 78 yards and two touchdowns. Thirty-five of those yards came after the catch.
Defensive spotlight: Among the many Jaguars pass-rushers to record multiple pressures on the day, Josh Allen posted a game-high four, including two sacks. He earned an 85.0 pass-rushing grade on first review.
Rookie spotlight: No. 1 overall pick Travon Walker chipped in with three pressures on the day — one hit and two hurries. He also made two tackles in the run game, including one stop.
Offensive line spotlight: The Colts' offensive line was charged with 10 pressures allowed. Matt Pryor and Danny Pinter were the biggest culprits, with each surrendering three pressures.
Box Score
Passing
| Indianapolis Colts | ||||||
| Player | Fantasy | Comp/Att | Yds | YPA | TD | Int |
| Matt Ryan | 4.8 | 16 / 30 | 195 | 6.5 | 0 | 3 |
| Jacksonville Jaguars | ||||||
| Player | Fantasy | Comp/Att | Yds | YPA | TD | Int |
| Trevor Lawrence | 18.5 | 25 / 30 | 235 | 7.8 | 2 | 0 |
Rushing
| Indianapolis Colts | ||||||
| Player | Fantasy | Car | Yds | YPC | TD | Long |
| Ashton Dulin | 13.2 | 1 | 3 | 3 | 0 | 3 |
| Nyheim Hines | 7.7 | 1 | 0 | 0 | 0 | 0 |
| Jonathan Taylor | 7.3 | 9 | 54 | 6 | 0 | 21 |
| Deon Jackson | -0.3 | 2 | -3 | -1.5 | 0 | 1 |
| Jacksonville Jaguars | ||||||
| Player | Fantasy | Car | Yds | YPC | TD | Long |
| Trevor Lawrence | 18.5 | 3 | 11 | 3.7 | 0 | 8 |
| James Robinson | 15.8 | 23 | 64 | 2.8 | 1 | 37 |
| Travis Etienne Jr. | 8.3 | 9 | 20 | 2.2 | 0 | 6 |
| Jamal Agnew | 0.1 | 2 | 1 | 0.5 | 0 | 2 |
Receiving
| Indianapolis Colts | ||||||
| Player | Fantasy | Tgt | Rec | Yds | YPT | TD |
| Ashton Dulin | 13.2 | 7 | 5 | 79 | 11.3 | 0 |
| Nyheim Hines | 7.7 | 5 | 4 | 37 | 7.4 | 0 |
| Jonathan Taylor | 7.3 | 1 | 1 | 9 | 9 | 0 |
| Dezmon Patmon | 4.4 | 6 | 2 | 24 | 4 | 0 |
| Kylen Granson | 3.4 | 2 | 2 | 14 | 7 | 0 |
| Mike Strachan | 3.3 | 3 | 1 | 23 | 7.7 | 0 |
| Mo Alie-Cox | 1.9 | 3 | 1 | 9 | 3 | 0 |
| Parris Campbell | 0 | 2 | 0 | 0 | 0 | 0 |
| Jacksonville Jaguars | ||||||
| Player | Fantasy | Tgt | Rec | Yds | YPT | TD |
| Christian Kirk | 25.8 | 6 | 6 | 78 | 13 | 2 |
| James Robinson | 15.8 | 2 | 2 | 14 | 7 | 0 |
| Evan Engram | 11.6 | 8 | 7 | 46 | 5.8 | 0 |
| Travis Etienne Jr. | 8.3 | 3 | 3 | 33 | 11 | 0 |
| Marvin Jones Jr. | 6.3 | 5 | 3 | 33 | 6.6 | 0 |
| Zay Jones | 5.3 | 4 | 3 | 23 | 5.8 | 0 |
| Dan Arnold | 1.8 | 1 | 1 | 8 | 8 | 0 |
| Jamal Agnew | 0.1 | 1 | 0 | 0 | 0 | 0 |