The 2022 NFL season kicks off Thursday, Sept. 8 with a blockbuster between the Buffalo Bills and Los Angeles Rams.
Take a look at the odds for every Week 1 game, courtesy of Bet MGM.
LAR @ BUF | BLT @ NYJ | NO @ ATL | NE @ MIA | CLV @ CAR | PIT @ CIN |
SF @ CHI | PHI @ DET | IND @ HST | JAX @ WAS | KC @ ARZ | LV @ LAC |
GB @ MIN | NYG @ TEN | TB @ DAL | DEN @ SEA
Last updated: Monday, September 5
Thursday, Sept. 8
Los Angeles Rams @ Buffalo Bills
| Spread | Total | Moneyline | |
| Buffalo Bills | -2.5 (-110) | o52.5 (-110) | -140 |
| Los Angeles Rams | +2.5 (-110) | u52.5 (-110) | +115 |
Bet Cooper Kupp to go over 7.5 receptions (-125 on BetMGM): PFF's simulation has Kupp hitting this total and gives this bet a 12.4% edge.
Bet Devin Singletary to go under 2.5 receptions (-130 on DraftKings): PFF's fantasy football projections have Singletary catching one pass for 6.8 yards, making his 2.5-catch reception prop a good bet Thursday night.
Sunday, Sept. 11
Baltimore Ravens @ New York Jets
| Spread | Total | Moneyline | |
| Baltimore Ravens | -7 (-105) | o44.5 (-110) | -300 |
| New York Jets | +7 (-115) | u44.5 (-110) | +240 |
New Orleans Saints @ Atlanta Falcons
| Spread | Total | Moneyline | |
| New Orleans Saints | -5.5 (-110) | o42.5 (-110) | -225 |
| Atlanta Falcons | +5.5 (-110) | u42.5 (-110) | +185 |
New England Patriots @ Miami Dolphins
| Spread | Total | Moneyline | |
| New England Patriots | +3 (-110) | o46.5 (-110) | +130 |
| Miami Dolphins | -3 (-110) | u46.5 (-110) | -155 |
Cleveland Browns @ Carolina Panthers
| Spread | Total | Moneyline | |
| Cleveland Browns | +2.5 (-110) | o41.5 (-110) | +110 |
| Carolina Panthers | -2.5 (-110) | u41.5 (-110) | -135 |
Pittsburgh Steelers @ Cincinnati Bengals
| Spread | Total | Moneyline | |
| Pittsburgh Steelers | +6.5 (-110) | o44.5 (-110) | +225 |
| Cincinnati Bengals | -6.5 (-110) | u44.5 (-110) | -275 |
San Francisco 49ers @ Chicago Bears
| Spread | Total | Moneyline | |
| San Francisco 49ers | -7 (-110) | o41.5 (-110) | -300 |
| Chicago Bears | +7 (-110) | u41.5 (-110) | +240 |
Philadelphia Eagles @ Detroit Lions
| Spread | Total | Moneyline | |
| Philadelphia Eagles | -4 (-110) | o48.5 (-110) | -200 |
| Detroit Lions | +4 (-110) | u48.5 (-110) | +165 |
Indianapolis Colts @ Houston Texans
| Spread | Total | Moneyline | |
| Indianapolis Colts | -8.5 (-110) | o45.5 (-110) | -375 |
| Houston Texans | +8.5 (-110) | u45.5 (-110) | +290 |
Jacksonville Jaguars @ Washington Commanders
| Spread | Total | Moneyline | |
| Jacksonville Jaguars | +3 (-110) | o43.5 (-110) | +135 |
| Washington Commanders | -3 (-110) | u43.5 (-110) | -165 |
Kansas City Chiefs @ Arizona Cardinals
| Spread | Total | Moneyline | |
| Kansas City Chiefs | -4.5 (-110) | o53.5 (-110) | -200 |
| Arizona Cardinals | +4.5 (-110) | u53.5 (-110) | +165 |
Las Vegas Raiders @ Los Angeles Chargers
| Spread | Total | Moneyline | |
| Las Vegas Raiders | +3.5 (-110) | o52.4 (-110) | +150 |
| Los Angeles Chargers | -3.5 (-110) | u52.5 (-110) | -185 |
Green Bay Packers @ Minnesota Vikings
| Spread | Total | Moneyline | |
| Green Bay Packers | -1.5 (-110) | o48.5 (-110) | -125 |
| Minnesota Vikings | +1.5 (-110) | u48.5 (-110) | +105 |
New York Giants @ Tennessee Titans
| Spread | Total | Moneyline | |
| New York Giants | +6 (-110) | o43.5 (-110) | +200 |
| Tennessee Titans | -6 (-110) | u43.5 (-110) | -250 |
Tampa Bay Buccaneers @ Dallas Cowboys
| Spread | Total | Moneyline | |
| Tampa Bay Buccaneers | -1.5 (-110) | o50.5 (-105) | -125 |
| Dallas Cowboys | +1.5 (-110) | u50.5 (-115) | +105 |
Monday, Sept. 12
Denver Broncos @ Seattle Seahawks
| Spread | Total | Moneyline | |
| Denver Broncos | TBD | TBD | TBD |
| Seattle Seahawks | TBD | TBD | TBD |
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