Chaos within the San Francisco 49ers backfield opens the door to a staring role for mid-round rookie darling Trey Sermon.

Ahead of a divisional showdown versus the Cincinnati Bengals, the Steelers will be without a handful of starters headlined by the absence of star edge-rusher T.J. Watt.

Your home for all of PFF's betting content ahead of Week 3 of the NFL season and Week 4 of the college football season.

Breaking down the best bets for college football's Week 4 slate, which includes Notre Dame vs. Wisconsin.

Breaking down the best last-minute bets for Week 3 in the NFL, which includes a parlay in the Arizona Cardinals-Jacksonville Jaguars game.

Each week, PFF injury analyst Mario Pilato will comb through the official injury reports for each NFL game and give updates and analysis for fantasy-relevant players.

Cleveland Browns wide receiver Odell Beckham Jr. will make his return to the field in Week 3 against the Chicago Bears.

Arizona Cardinals WR DeAndre Hopkins has been ruled a game-time decision vs. Jacksonville Jaguars in Week 3 due to a rib issue.

Minnesota Vikings running back Dalvin Cook, a fantasy football mainstay, is officially listed as questionable for his team's Week 3 matchup with the Seattle Seahawks.

Sam Darnold has now racked up 888 passing yards across three games and has looked like a different player since Carolina traded for him -- and picked up his fifth-year option -- this offseason. But how much of this reclamation project is for real, and how much is an illusion?

Though he received significant carries when he started at Wake Forest, Kenneth Walker is making even bigger waves with the Michigan State Spartans. He's even looking at odds for the Heisman Trophy — a goal that he has had for years.

PFF analysts Andrew Erickson and Ben Brown make their PrizePicks for Week 3 of the 2021 NFL Season.

Breaking down the top smash, upgrade and fade plays for fantasy football Week 3 by integrating NFL totals, spreads, implied points and proprietary PFF matchup data.

Breaking down the top-100 prospects in the 2022 NFL Draft, which includes Ohio State's Garrett Wilson as the top-ranked WR.

Second-year wide receiver Van Jefferson discusses his progression in the NFL and where he gets his underrated route-running chops.

Identifying the best DFS stacks for the Week 3 DFS main slate by projecting the likelihood of each individual QB, RB, WR, TE and DST finishing as the highest-scoring player.

Examining four schematic matchups that will lead to offensive advantages for fantasy football during Week 3 of the 2021 NFL season.

The contest between Tennessee Titans WR Julio Jones and Indianapolis Colts CB T.J. Carrie stands out as a matchup to target, while fantasy managers would be wise to avoid Tampa Bay's Chris Godwin as he goes up against Los Angeles' Jalen Ramsey.