NFL Week 1 Betting Guide

Cincinnati, Ohio, USA; Cincinnati Bengals quarterback Joe Burrow (9) throws during the first quarter against the Miami Dolphins at Paul Brown Stadium. Mandatory Credit: Joseph Maiorana-USA TODAY Sports

By PFF.com
Posted Sep 11, 2021 5:30 am EDT

PFF's weekly betting guide is your go-to reference for placing those all-important NFL and college football bets, whether you're wagering on the game's spread, total or player props.

Here you can find everything from NFL player props and futures bets to college football spread and under/over value picks. All predictions have been made with the help of PFF Greenline, which uses exclusive game and player data to make projections on NFL game spreads, moneyline, and over/under.

Click here for more PFF tools:

Rankings & Projections | WR/CB Matchup Chart | NFL & NCAA Betting Dashboards | NFL Player Props tool | NFL & NCAA Power Rankings

Use PFF's Betting Dashboard and Player Props Tool to get the most value out of every Week 1 NFL game

NFL PICKS

Best NFL Week 1 spread picks

Best NFL Week 1 single-game & player props bets

Best NFL Week 1 teasers & parlays

Best NFL Week 1 last-minute bets

Four best NFL Week 1 Sunday player props bets

PrizePicks Week 1 Preview

2021 NFL win totals tracker

Best Bets on Rookie QB Player Props: Trevor Lawrence over 13.5 INTs, Zach Wilson under 21.5 TDs and more

How NFL offensive line continuity affects the betting markets

COLLEGE FOOTBALL PICKS

Best college football Week 2 teaser & parlay bets

College Football Betting 2021: Best Week 2 spread picks

College Football Week 2: Schedule, odds, picks and game previews

College Football Betting 2021: Week 2 college football over/under value picks

College Football Betting 2021: Best Late Week 2 Bets — spread, total & moneyline

Best last-minute college football bets ahead of Week 2

Best Bets

PFF's Best Bets Tool reveals the bets PFF's data and algorithms give the biggest edge to within spread, total, player prop, and moneyline markets.

Available with
NFL Power Rankings

Power Rankings are PFF’s NFL power ratings based on weekly player grades in each facet of play. These power rankings are adjusted based on coach, quarterback and the market each season.

Available with
NFL Scores & Schedule

PFF predictions and real time spread, moneyline and over/under lines for each NFL game.

Available with
NCAA Scores & Schedule

PFF predictions and real time spread, moneyline and over/under lines for each NCAA game.

Available with