The No. 1 overall pick assembled the best game in his young career in Week 5.

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The New England Patriots pulled off a stunning 23-20 victory over the previously unbeaten Buffalo Bills in Orchard Park, marking their first set of back-to-back wins since 2022. With the loss, the Bills drop their first game of the season, leaving no undefeated teams remaining in the NFL. Rookie quarterback Drake Maye and veteran wide receiver Stefon Diggs were exceptional, powering the Patriots to the upset.

The Titans snapped a 10-game losing streak with a dramatic 22-21 comeback win over the Cardinals, capped by Joey Slye’s game-winning 29-yard field goal as time expired. Trailing 21-6 in the fourth quarter, Cam Ward led two touchdown drives and a late field goal march, with help from a bizarre fumble-recovery score by Tyler Lockett. The win moves Tennessee to 1-4 after a previously winless start.

Jake Browning's three interceptions ultimately doomed the Bengals in Week 5, despite their best efforts to mount a comeback against the high-flying Lions.

The Commanders erased a 10-point deficit by scoring 27 unanswered points to beat the Chargers 27-10, fueled by Jacory Croskey-Merritt’s two rushing touchdowns. Jayden Daniels threw for 231 yards and a late touchdown in his return, while Washington’s defense pressured Justin Herbert into four sacks.

The Buccaneers just won't quit. Despite being down Bucky Irving and several others, Baker Mayfield and Emeka Egbuka carried the load for Tampa's offense, connecting seven times for 163 yards and a score. A Lavonte David interception with 58 seconds left catalyzed a walk-off field goal from Chase McLaughlin, pushing Tampa Bay to 4-1.

The Broncos stormed back from a quiet three quarters to outscore the Eagles 18-0 in the fourth, outgaining them 156-15 in a dominant final frame. Philadelphia had one last chance, but Jalen Hurts’ Hail Mary fell incomplete in a crowded end zone, sealing Denver’s comeback win.

The Saints snapped a four-game losing streak with a 26-14 win over the Giants, earning Kellen Moore his first victory as head coach and Spencer Rattler his first as a starting quarterback. Rattler connected with Rashid Shaheed for an 87-yard touchdown — the longest Saints play since 2016 — to spark the offense. The defense also came up big, helping New Orleans move to 1-4 on the season.

The Dolphins blew a 17-point first-quarter lead in a 27-24 loss to the Panthers, falling to 1-4 on the season. Despite early success from Tua Tagovailoa and a pair of forced turnovers, Miami’s offense stalled after halftime while the defense gave up explosive plays to Carolina’s Rico Dowdle and Bryce Young. A late Panthers touchdown and Miami’s failed final possession sealed an embarrassing collapse for a team still searching for consistency.

Ryan Flournoy and Javonte Williams led the charge for the Cowboys' offense, while the team's defense limited the Jets to just three first-half points.

The injury-riddled Ravens were no match for the Texans, who have turned things around after an 0-3 start to the campaign.

Jonathan Taylor's three touchdowns powered the Colts to a blowout win over the Raiders in Week 5.

The Vikings edged the Browns 21–17 at Tottenham Hotspur Stadium in London. Despite falling behind late, quarterback Carson Wentz led a fourth-quarter comeback, marching Minnesota down the field with key completions to wide receivers Justin Jefferson and Jordan Addison.

Dealing with a bevy of injuries to key players, the 49ers rode Mac Jones and company to a hard-fought Week 5 win over the Rams.

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Despite missing their starting quarterback, star tight end and top wide receivers, the San Francisco 49ers gutted out a hard-fought 26-23 win over the Los Angeles Rams to kick off Week 5.

We're diving into all 14 matchups in Week 5 of the 2025 NFL season — including key storylines, matchups to watch and injury news, starting with 49ers-Rams.