The San Francisco 49ers held on for a 41-33 win over the Detroit Lions despite watching their 28-point lead reduced to just 8 during the game’s final minutes.

The Carolina Panthers suffocated a young New York Jets team in the Sam Darnold Revenge Game, scoring just enough to get the 19-14 win.

Jalen Hurts had a career day and rookie receiver Devonta Smith caught his first career touchdown pass as the Philadelphia Eagles routed the Atlanta Falcons, 32-6, during Week 1 of the 2021 NFL season.

While the Minnesota Vikings forced overtime with a late field goal, quarterback Joe Burrow was triumphant in his return from a serious knee injury as the Bengals hung on for a 27-24 win in Week 1 of the 2021 NFL season.

Seattle Seahawks quarterback Russell Wilson carved up the Indianapolis Colts defense like a hot knife en route to a 28-16 Week 1 win.

The Houston Texans took a 20-point lead into halftime and cruised to a 37-21 victory over the Jacksonville Jaguars, spoiling Trevor Lawrence's debut in Week 1 of the 2021 NFL season.

The Pittsburgh Steelers pulled off a surprise win over Josh Allen and the Buffalo Bills in Week 1 of the 2021 NFL season.

A late fumble from running back Antonio Gibson gave new life to the Los Angeles Chargers, who eked out a 20-16 win over the Washington Football Team in Week 1 of the 2021 NFL season.

Per ESPN’s Adam Schefter, the San Francisco 49ers traded up to No. 3 overall in the 2021 NFL Draft partly in fear that the New England Patriots would trade up for quarterback Mac Jones.

Get all the betting information you need for Sunday night's Los Angeles Rams-Chicago Bears contest.

There is a bevy of player props that can put cash in your pockets in Week 1, including New Orleans Saints RB Alvin Kamara's reception prop.

The New Orleans Saints downgrade cornerback Marshon Lattimore to questionable Saturday, and there's a chance he may miss the Saints' Week 1 game vs. Packers

The Indianapolis Colts will have two key starters back Week 1, as quarterback Carson Wentz and left guard Quenton Nelson will play against the Philadelphia Eagles Sunday.

The Kansas City Chiefs activated star defensive back Tyrann Mathieu from the COVID-19 list Saturday.

As the season nears its beginning, the Eagles agree to a long-term deal with hidden gem left tackle Jordan Mailata.

The Detroit Lions placed left tackle Taylor Decker on injured reserve Saturday, and he will likely be replaced by rookie Penei Sewell, who slides over from right tackle.

Los Angeles Chargers running back Austin Ekeler is expected to play Sunday against the Washington Football Team despite practicing just one day this week with a limited designation.

Chicago Bears QB Justin Fields should be the NFL's best rookie QB this season, and this PFF data study reveals why.