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NFL Week 5 Odds and Best Bets

October 3, 2021; Santa Clara, California, USA; San Francisco 49ers quarterback Trey Lance (5) passes the football against the Seattle Seahawks during the third quarter at Levi's Stadium. Mandatory Credit: Kyle Terada-USA TODAY Sports

Week 5 NFL odds are live, and the best time to bet them is now — before the lines move. We went 4-1 last week (including our lock of the week, which can be found on the PFF Forecast podcast) with one play left to go on Monday Night Football.

Equally as important, we saw closing line value (the line we bet in this article is better than the closing line with respect to the side we bet) on every single write-up from this article in Week 4.

Related: Why betting early is critical to beating NFL markets via Robert Greer

We’re on to Week 5, which has a number of intriguing options based on early betting odds. All our initial reactions and guessing of the lines can be found on the PFF Forecast, which airs LIVE directly after Sunday Night Football and again Wednesday evening.

Click here for more PFF tools:

Rankings & ProjectionsWR/CB Matchup ChartNFL & NCAA Betting DashboardsNFL Player Props toolNFL & NCAA Power Rankings


Week 5 NFL Football Betting Odds (spread, total)

Find all current spreads and PFF’s model predictions on our NFL scores page

Thursday Night Football

Los Angeles Rams @ Seattle Seahawks (+1, 51.5)

Sunday 1PM ET

New York Jets vs. Atlanta Falcons  (-3.5, 44) — in London

Philadelphia Eagles @ Carolina Panthers (-4.5, 46)

New Orleans Saints @ Washington Football Team (+1, 44)

Tennessee Titans @ Jacksonville Jaguars (+3.5, 48)

Detroit Lions @ Minnesota Vikings (-8, 49)

Green Bay Packers @ Cincinnati Bengals (+4, 49.5)

New England Patriots @ Houston Texans (+9.5, 39.5)

Denver Broncos @ Pittsburgh Steelers (+1.5, 40.5)

Miami Dolphins @ Tampa Bay Buccaneers (-10.5, 49.5)

Sunday 4PM ET

Cleveland Browns @ Los Angeles Chargers (-1.5, 49.5)

Chicago Bears @ Las Vegas Raiders (-5.5, 45.5)  

New York Giants @ Dallas Cowboys (-7.5, 50.5)

San Francisco 49ers @ Arizona Cardinals (-4.5, 53.5)

Sunday Night Football

Buffalo Bills @ Kansas City Chiefs (-2.5, 56.5)

Monday Night Football

Indianapolis Colts @ Baltimore Ravens (-7, 48)          

Week 5 Best Early NFL Bets

Los Angeles Rams (-1.5) @ Seattle Seahawks

Point (George Chahrouri): The Rams predictably fell short after their huge win against Tom Brady and the Tampa Bay Buccaneers in Week 3. Meanwhile, the Seahawks beat a San Francisco 49ers team that needed to make a quarterback switch midway through the game.

Not only does Sean McVay’s offense torch the Cover 3 Seahawks, but the Rams' defensive stars also thrive against Seattle, with Aaron Donald getting to face an interior offensive line without a player who ranks in the top 40 at their position in PFF grade and Jalen Ramsey battling D.K. Metcalf, who was held to 87 combined yards in two contests last year. The Rams recover from their embarrassing loss to Arizona.

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