| Tm | Starter | Handcuff(s) | Value if Starter |
| ARZ | Kyler Murray | Brett Hundley | Bottom 5 |
| ATL | Matt Ryan | Matt Schaub | Bottom 5 |
| BLT | Lamar Jackson | Robert Griffin | QB3 |
| BUF | Josh Allen | Matt Barkley | Bottom 5 |
| CAR | Cam Newton | Kyle Allen | QB2 |
| CHI | Mitchell Trubisky | Chase Daniel | QB2 |
| CIN | Andy Dalton | Ryan Finley | Bottom 5 |
| CLV | Baker Mayfield | Drew Stanton | QB2 |
| DAL | Dak Prescott | Cooper Rush | Bottom 5 |
| DEN | Joe Flacco | Brandon Allen | Bottom 5 |
| DET | Matthew Stafford | Josh Johnson | QB2 |
| GB | Aaron Rodgers | Tim Boyle | QB3 |
| HST | Deshaun Watson | A.J. McCarron | QB3 |
| IND | Jacoby Brissett | Brian Hoyer | Fringe QB2 |
| JAX | Gardner Minshew | Josh Dobbs | Bottom 5 |
| KC | Patrick Mahomes | Matt Moore | QB3 |
| LA | Jared Goff | Blake Bortles | Fringe QB2 |
| LAC | Philip Rivers | Tyrod Taylor | QB2 |
| MIA | Josh Rosen | Ryan Fitzpatrick | Fringe QB2 |
| MIN | Kirk Cousins | Sean Mannion | QB3 |
| NE | Tom Brady | Jarrett Stidham | QB2 |
| NO | Teddy Bridgewater | Taysom Hill | QB2 |
| NYG | Daniel Jones | Eli Manning | QB3 |
| NYJ | Sam Darnold | Luke Falk | Back-end QB2 |
| OAK | Derek Carr | Mike Glennon | Bottom 5 |
| PHI | Carson Wentz | Josh McCown | QB2 |
| PIT | Mason Rudolph | Devlin Hodges | Bottom 5 |
| SEA | Russell Wilson | Geno Smith | QB2 |
| SF | Jimmy Garoppolo | Nick Mullens | Fringe QB2 |
| TB | Jameis Winston | Ryan Griffin | Bottom 5 |
| TEN | Ryan Tannehill | Marcus Mariota | Fringe QB2 |
| WAS | Case Keenum | Dwayne Haskins | Fringe QB2 |
| Tm | Early Down | Passing Down | Handcuff(s) | Value if Starter |
| ARZ | David Johnson | David Johnson | Chase Edmonds | RB2 |
| ATL | Devonta Freeman | Devonta Freeman | Ito Smith | RB2 |
| BLT | Mark Ingram | Mark Ingram | Gus Edwards | RB2 |
| BUF | Frank Gore | Devin Singletary | Devin Singletary | RB2 |
| CAR | Christian McCaffrey | Christian McCaffrey | Reggie Bonnafon | Flex |
| CHI | David Montgomery | Tarik Cohen | Mike Davis | RB2 |
| CIN | Joe Mixon | Joe Mixon | Giovani Bernard | RB1 |
| CLV | Nick Chubb | Nick Chubb | Dontrell Hilliard | Flex |
| DAL | Ezekiel Elliott | Ezekiel Elliott | Tony Pollard | RB1 |
| DEN | Phillip Lindsay | Royce Freeman | Devontae Booker | Flex |
| DET | Kerryon Johnson | Kerryon Johnson | Ty Johnson | Flex |
| GB | Aaron Jones | Aaron Jones | Jamaal Williams | RB2 |
| HST | Carlos Hyde | Duke Johnson | Buddy Howell | Flex |
| IND | Marlon Mack | Nyheim Hines | Jordan Wilkins | RB2 |
| JAX | Leonard Fournette | Leonard Fournette | Ryquell Armstead | Flex |
| KC | LeSean McCoy | Damien Williams | Darrel Williams | RB2 |
| LA | Todd Gurley | Todd Gurley | Malcolm Brown | RB2 |
| MIA | Kenyan Drake | Kenyan Drake | Kalen Ballage | Flex |
| MIN | Dalvin Cook | Dalvin Cook | Alexander Mattison | RB1 |
| NE | Sony Michel | James White | Rex Burkhead | RB2 |
| NO | Alvin Kamara | Alvin Kamara | Latavius Murray | RB1 |
| NYG | Saquon Barkley | Saquon Barkley | Wayne Gallman | RB2 |
| NYJ | Le’Veon Bell | Le’Veon Bell | Ty Montgomery | Flex |
| OAK | Josh Jacobs | Josh Jacobs | DeAndre Washington | Back-end RB2 |
| PHI | Jordan Howard | Miles Sanders | Boston Scott | Flex |
| PIT | James Conner | James Conner | Benny Snell | RB2 |
| LAC | Melvin Gordon | Melvin Gordon | Austin Ekeler | RB1 |
| SEA | Chris Carson | Chris Carson | Rashaad Penny | RB1 |
| SF | Tevin Coleman | Matt Brieda | Raheem Mostert | RB2 |
| TB | Ronald Jones | Dare Ogunbwale | Peyton Barber | RB2 |
| TEN | Derrick Henry | Dion Lewis | David Fluellen | Flex |
| WAS | Adrian Peterson | Chris Thompson | Wendell Smallwood | RB3 |
| Tm | No. 1 | No. 2 | No. 3 | Value if No. 3 Becomes Top 2 |
| ARZ | Larry Fitzgerald | Christian Kirk | KeeSean Johnson | WR5 |
| ATL | Julio Jones | Calvin Ridley | Mohamed Sanu | WR4 |
| BLT | Marquise Brown | Willie Snead | Miles Boykin | WR5 |
| BUF | John Brown | Cole Beasley | Duke Williams | WR5 |
| CAR | D.J. Moore | Curtis Samuel | Jarius Wright | WR5 |
| CHI | Allen Robinson | Taylor Gabriel | Anthony Miller | WR4 |
| CIN | A.J. Green | Tyler Boyd | Auden Tate | WR5 |
| CLV | Odell Beckham | Jarvis Landry | Antonio Callaway | WR3 |
| DAL | Amari Cooper | Michael Gallup | Randall Cobb | WR4 |
| DEN | Emmanuel Sanders | Courtland Sutton | DaeSean Hamilton | WR3 |
| DET | Kenny Golladay | Marvin Jones | Danny Amendola | WR5 |
| GB | Davante Adams | Marquez Valdes-Scantling | Geronimo Allison | WR4 |
| HST | DeAndre Hopkins | Will Fuller | Kenny Stills | WR3 |
| IND | T.Y. Hilton | Chester Rogers | Zach Pascal | WR5 |
| JAX | D.J. Chark | Dede Westbrook | Chris Conley | WR5 |
| KC | Tyreek Hill | Sammy Watkins | Demarcus Robinson | WR3 |
| LA | Cooper Kupp | Brandin Cooks | Robert Woods | WR2 |
| LAC | Keenan Allen | Mike Williams | Travis Benjamin | WR4 |
| MIA | Preston Williams | DeVante Parker | Albert Wilson | WR5 |
| MIN | Adam Thielen | Stefon Diggs | Bisi Johnson | WR5 |
| NE | Julian Edelman | Josh Gordon | Phillip Dorsett | WR2 |
| NO | Michael Thomas | Ted Ginn | Tre’Quan Smith | WR3 |
| NYG | Sterling Shepard | Golden Tate | Cody Lattimer | WR5 |
| NYJ | Jamison Crowder | Robby Anderson | Demaryius Thomas | WR5 |
| OAK | Tyrell Williams | Hunter Renfrow | Zay Jones | WR4 |
| PHI | Alshon Jeffery | DeSean Jackson | Nelson Agholor | WR3 |
| PIT | JuJu Smith-Schuster | Diontae Johnson | James Washington | WR4 |
| SF | Marquise Goodwin | Deebo Samuel | Richie James Jr. | WR4 |
| SEA | Tyler Lockett | D.K. Metcalf | Jaron Brown | WR5 |
| TB | Mike Evans | Chris Godwin | Breshad Perriman | WR4 |
| TEN | Corey Davis | A.J. Brown | Adam Humphries | WR4 |
| WAS | Terry McLaurin | Paul Richardson | Trey Quinn | WR4 |
| Tm | Starter | Handcuff | Value if Starter |
| ARZ | Charles Clay | Maxx Williams | TE3 |
| ATL | Austin Hooper | Luke Stocker | TE3 |
| BLT | Mark Andrews | Hayden Hurst | TE2 |
| BUF | Dawson Knox | Tyler Kroft | TE3 |
| CAR | Greg Olsen | Ian Thomas | TE2 |
| CHI | Trey Burton | Adam Shaheen | TE2 |
| CIN | Tyler Eifert | C.J. Uzomah | TE2 |
| CLV | Ricky Seals-Jones | Demetrius Harris | TE3 |
| DAL | Jason Witten | Blake Jarwin | TE3 |
| DEN | Noah Fant | Jeff Heuerman | TE3 |
| DET | T.J. Hockenson | Jesse James | TE2 |
| GB | Jimmy Graham | Marcedes Lewis | TE3 |
| HST | Jordan Akins | Darren Fells | TE3 |
| IND | Jack Doyle | Eric Ebron | TE2 |
| JAX | Geoff Swaim | Josh Oliver | TE3 |
| KC | Travis Kelce | Blake Bell | TE2 |
| LA | Gerald Everett | Tyler Higbee | TE2 |
| LAC | Hunter Henry | Virgil Green | TE3 |
| MIA | Mike Gesicki | Nick O’Leary | TE3 |
| MIN | Kyle Rudolph | Irv Smith Jr. | TE2 |
| NE | Ryan Izzo | Ben Watson | TE3 |
| NO | Jared Cook | Josh Hill | TE3 |
| NYG | Evan Engram | Rhett Ellison | TE3 |
| NYJ | Chris Herndon | Ryan Griffin | TE3 |
| OAK | Darren Waller | Foster Moreau | TE3 |
| PHI | Zach Ertz | Dallas Goedert | TE1 |
| PIT | Vance McDonald | Nick Vannett | TE2 |
| SEA | Luke Willson | Jacob Hollister | TE3 |
| SF | George Kittle | Levine Toilolo | TE3 |
| TB | O.J. Howard | Cameron Brate | TE1 |
| TEN | Delanie Walker | Jonnu Smith | TE2 |
| WAS | Vernon Davis | Jeremy Sprinkle | TE2 |