The New York Giants' run-heavy approach paid off in a 24-16 victory over the Houston Texans in Week 10.

The Minnesota Vikings won the game of the season in overtime, knocking off the Buffalo Bills, 33-30, in Week 10.

Chiefs quarterback Patrick Mahomes put on a clinic to finish 26-of-35 for 331 yards with four scores and one interception in his team's 27-17 win over the Jacksonville Jaguars and Trevor Lawrence in Week 10.

The Miami Dolphins took care of the Cleveland Browns with relative ease to emerge victorious by a score of 39-17 in Week 10.

The Lions outlasted quarterback Justin Fields and the Chicago Bears 31-30 in an NFC North battle on the road at Soldier Field behind an impressive 10-catch, 119-yard performance by wide receiver Amon-Ra St. Brown.

PFF staff best bets in Los Angeles Chargers-San Francisco 49ers on SNF in Week 10, including 49ers WR Jauan Jennings u1.5 receptions.

In a back-and-forth game, the Pittsburgh Steelers were able to defend their home field against the visiting New Orleans Saints, winning by a score of 20-10.

PFF staff best bets in the late-Sunday window in Week 10, including Colts RB Jonathan Taylor's under rushing-yardage prop.

The Tampa Bay Buccaneers got ahead early and held on through a hard-fought fourth quarter to beat the Seattle Seahawks 21-16 in Week 10. 

Among the PFF staff best bets in the early-afternoon Sunday window in Week 10 include Justin Fields o59.5 rush yards vs the Detroit Lions.

Judah Fortgang cooks up another Dolphins SGP in Week 10, when Jeff Wilson, Raheem Mostert provide Miami pass game a powerful counterpunch in running past Cleveland Browns.

Take a look at the odds for every Week 10 game, courtesy of BetMGM, followed by PFF Greenline and PFF staff best bets.

Bet Seattle Seahawks RB Kenneth Walker u10.5 receiving yards at Tampa Bay Bucs, Arjun Menon writes in his top data-driven player-props column in Week 10.

The 8-0 Philadelphia Eagles are firing on all cylinders through nine weeks of the 2022 NFL season, with multiple units and players excelling.

In his Week 10 live-betting gameplan, Judah Fortgang is preparing to bet on the Dallas Cowboys team total over and alt line as an elite offense at running up the score looks to do that against Aaron Rodgers and Co. at Lambeau.

Dallas Cowboys edge defender Micah Parsons unsurprisingly leads the way among second-year NFL players ahead of Week 10.

Baltimore Ravens tight end Mark Andrews leads the way in the red zone as quarterback Lamar Jackson's favorite target.

PFF's Doug Kyed drops his weekly mailbag, answering questions about Geno Smith and the Seattle Seahawks in 2023, the New England Patriots tipping plays and more.