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2022 NFL Playoffs Divisional Round Odds and Best Bets

Arlington, Texas, USA; San Francisco 49ers running back Elijah Mitchell (25) celebrates his touchdown against the Dallas Cowboys with teammates on the field during the first half of the NFC Wild Card playoff football game at AT&T Stadium. Mandatory Credit: Kevin Jairaj-USA TODAY Sports

The divisional round of the NFL playoffs is (almost) here, and while we still get the privilege of watching Matthew Stafford and the Los Angeles Rams take on the Arizona Cardinals tonight, spreads and totals for next week are up. 

We are 1-2 so far in the wild-card round, getting to the window with the San Francisco 49ers. Our pick of the week, which is now 11-10, was the New England Patriots, who made the Buffalo Bills look like the ‘72 Miami Dolphins. We move on.

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Why betting early is critical to beating NFL markets via Robert Greer

Make sure you check PFF’s betting dashboards when our weekly model predictions go live on Tuesdays, and of course, monitor the Best Bets and Player Props tools to find the very best betting value as college football bowl season and the NFL regular season wind down. Both the NFL and NCAA betting dashboards are plus-30 or more units on the season against early lines and are positive against closing lines as well.

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NFL Divisional Round Football Betting Odds (spread, total)

Find all current spreads and PFF’s model predictions on our NFL scores page


(4) Cincinnati Bengals @ (1) Tennessee Titans (-3, 47) | 4:35pm ET
(6) San Francisco 49ers @ (1) Green Bay Packers (-5.5, 47.5) | 8:15pm ET


(4/5) Los Angeles Rams/Arizona Cardinals @ (2) Tampa Bay Buccaneers | 3:05pm ET
(3) Buffalo Bills @ (2) Kansas City Chiefs (-2.5, 54) | 6:30 ET

Divisional Round Best Early NFL Bets

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