Saquon Barkley and Clyde Edwards-Helaire top the list of Week 5 NFL injuries that will impact fantasy football rankings and free agent strategy heading into Week 6 of the 2021 NFL season.

Breaking down fantasy football Week 6 waiver wire targets for all league sizes and scoring types, including Cincinnati Bengals running back Samaje Perine.

The Buffalo Bills completely controlled this highly anticipated Sunday Night Football affair — pre- and post-weather delay. In the end, the Kansas City Chiefs’ explosive passing attack was nowhere to be found, while Bills quarterback Josh Allen delivered numerous strikes downfield to lead Buffalo to a 38-20 victory.

The Dallas Cowboys dispatched the injury-ravaged New York Giants, who lost quarterback Daniel Jones and wide receiver Kenny Golladay in the contest, in Week 5 of the 2021 NFL season

In a highly competitive Week 5 game, the Los Angeles Chargers got the ball last and Austin Ekeler scored the go-ahead touchdown with 1:38 remaining to defeat the Cleveland Browns at home 47-42.

Kyler Murray and the Arizona Cardinals improved to 5-0 on the young season, shutting down Trey Lance and the San Francisco 49ers in a 17-10 victory.

The Chicago Bears jumped out to an early lead and then suffocated the Las Vegas Raiders to emerge as 20-9 victors in Week 5 of the 2021 NFL season.

The Green Bay Packers and Cincinnati Bengals combined to miss five kicks during the fourth quarter and overtime, but Mason Crosby eventually won it for the visiting Packers, 25-22.

The Jacksonville Jaguars remained winless, falling at the hands of running back Derrick Henry and the Tennessee Titans in Week 5 of the 2021 NFL season.

Jameis Winston threw four touchdown passes, including a second-half Hail Mary, and the New Orleans Saints outlasted the Washington Football Team 33-22 in Week 5. 

After a dramatic and emotional return to New England last week, Tom Brady and the Tampa Bay Buccaneers defeated the Jacoby Brissett-led Miami Dolphins 45-17. The defending Super Bowl champions move up to 4-1, while the Tua-less Dolphins fall to 1-4.

The Minnesota Vikings squandered a late lead to the still-winless Detroit Lions, but kicker Greg Joseph's game-winning field goal put them back on top for the win.

Jalen Hurts was just good enough for the Philadelphia Eagles to pull out the 21-18 win against the Carolina Panthers in Week 5 of the 2021 NFL season. 

Mac Jones led the New England Patriots' offense to 16 unanswered second-half points, and a Nick Folk field goal with 17 seconds remaining gave the Patriots a 25-22 win over the Houston Texans.

Diontae Johnson and Chase Claypool combined for 202 of the Pittsburgh Steelers' 253 receiving yards, helping the team hand the Denver Broncos their second loss in as many games.

All the momentum gained from the New York Jets' upset Week 4 win didn't make the plane trip across the pond, as the Atlanta Falcons coasted to a 27-20 victory over Zach Wilson and the Jets in Week 5 of the 2021 NFL season. 

The best Sunday Night single-game and player props for Week 5 are here with fireworks expected from Josh Allen and Patrick Mahomes.

The best player prop bets for Week 5 feature the likes of Cordarrelle Patterson and his combined rushing/receiving totals.