The first week of the 2021 NFL season is finally here. And that means it's time to set our fantasy football lineups in the hopes of optimizing our teams' scoring outputs.
Below you'll find tiers and rankings for every fantasy football skill position, including analysis, implied point totals, betting spreads and more.
For adjustments after the timestamp below, please see the weekly rankings.
Last Updated: Sunday 12:00 P.M.
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QUARTERBACK
TIER 1 – ELITE PASSER OR RUSHER + GOOD IMPLIED POINT TOTALS
| Rank | Player | Team | Opponent | Location | Total | Spread | Implied Points |
| QB1 | Patrick Mahomes | Chiefs | Browns | Home | 54.5 | -6.5 | 30.50 |
| QB2 | Lamar Jackson | Ravens | Raiders | Away | 50.5 | -4.5 | 27.50 |
| QB3 | Kyler Murray | Cardinals | Titans | Away | 52.5 | 3.0 | 24.75 |
| QB4 | Tom Brady | Buccaneers | Cowboys | Home | 51.5 | -8.0 | 29.75 |
Three of the summer's top ADP quarterbacks get premier matchups out of the gate, and Brady gets a juicy matchup versus Dallas.
TIER 2 – ELITE PASSER + GOOD IMPLIED TOTALS
| Rank | Player | Team | Opponent | Location | Total | Spread | Implied Points |
| QB5 | Josh Allen | Bills | Steelers | Home | 48.5 | -6.5 | 27.50 |
| QB6 | Russell Wilson | Seahawks | Colts | Away | 49.5 | -2.5 | 26.00 |
| QB7 | Aaron Rodgers | Packers | Saints | Away | 50.0 | -4.0 | 27.00 |
Allen roasted nearly every defense in the NFL last season, but the Steelers held the Bills to their sixth-lowest passing total of the season (238 yards). It was also Allen's sixth-lowest passing grade of the season (61.2). Pittsburgh pressured Allen on 46% of his dropbacks but could be without T.J. Watt, who is in a contract dispute.
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