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NFL Week 16 Fantasy Football Waiver Wire Targets: All league sizes & scoring types

Orchard Park, New York, USA; Buffalo Bills wide receiver Gabriel Davis (13) catches a pass for a touchdown against the Carolina Panthers during the second half at Highmark Stadium. Mandatory Credit: Rich Barnes-USA TODAY Sports

NFL Week 16 marks the second round of the 2021 fantasy football playoffs in most leagues, so it's time to identify the best waiver wire pickups who can help us plug any holes in starting lineups heading into the semifinals. 

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The likes of Teddy Bridgewater, Sterling Shepard, Pat Freiermuth, Julio Jones, Lamar Jackson, Emmanuel Sanders, Kareem Hunt, Elijah Mitchell, Adam Thielen, D’Andre Swift, Darren Waller, Kadarius Toney, Taylor Heinicke, Damien Harris and Nelson Agholor are dealing with injuries/COVID situations that could cost significant time in some cases.

RUNNING BACKS

Samaje Perine, CINCINNATI BENGALS

Joe Mixon was banged up in the team’s win over the Denver Broncos, so proactive fantasy managers should add Perine just in case Mixon’s injury is worse than initially reported

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