Week 6 features a ton of good players in great spots, and it’s actually going to be difficult to set lineups, because you’ll ultimately be forced to sit a few players who could smash this week.
Here’s a list of players you can lock into your Week 6 DFS lineups.
Note: There’s always a case to be made for playing any player in tournaments. This list of “locks” is cash game focused, but I typically like these players across all contest types.
Despite both entering Week 6 with 3-2 records, let’s not pretend like the Patriots and Jets are even on the same planet in terms of talent. The Pats are 9.5-point favorites and the Jets are a bottom-half team in terms of fantasy points given up to quarterbacks despite facing a bunch of bad signal-callers (Miami, Jacksonville, Cleveland in the past three weeks).
(It's PFF Fantasy's Free Content Week. Keep up with all the offerings here.)
Brees at home coming off a bye in a game with the week’s second-highest over-under (50)? Yes, please.
Cousins checks all the boxes this week. He’s a home favorite (by 11 points). He’s fresh (just had a bye week). His top target isn’t on the injury report anymore (Jordan Reed). And he’s been silky-smooth with efficiency (8.3 YPA, tied for third in NFL).
Watson has earned weekly must-start status after annihilating the NFL in recent weeks en route to his perch atop the fantasy points scored pile. And this week he gets the Browns, who have given up the fourth-most fantasy points to the position this year.
Hunt has rushed for over 100 yards in four of the first five games of his career. He’s nearly a must-play on DraftKings where he’s severely underpriced.
Fournette is second in the NFL in rushing yards (466) and first in attempts (109). He has also scored at least one touchdown in every game this year. He provides a safe floor and a massive ceiling. And this week he gets the Rams, who have given up the second-most fantasy points to the position and the most rushing touchdowns (6).
Gurley flopped in Week 5, but it’s safe to get back on the horse. His Week 6 opponent, the Jaguars, have given up the eighth-most fantasy points to running backs this year and have surrendered a putrid 5.4 YPC to opposing backs.
Mark Ingram, New Orleans Saints
Ingram (and teammate Alvin Kamara) are both popular plays this week. The matchup isn’t ideal, but Ingram is a home favorite in a projected high-scoring game, and he’s cheap on both sites. Kamara is a lock on DraftKings.
McKinnon didn’t get the salary bump he deserved because he played on Monday night. That makes him a fantastic value play in Week 6 and a DFS lock thanks on his salary-based projections. He out-snapped Latavius Murray 47-to-22 last week.
Pittsburgh’s offense has faltered several times this year, but Brown has remained constant. The Chiefs have given up the fourth-most fantasy points to enemy wideouts and have given up the (tied for) most touchdowns (9).
Michael Thomas, New Orleans Saints
Just play all of the Saints this week. A Darius Slay shadow situation shouldn’t pull you off of Thomas in New Orleans with such a high projected point total.
Jones has the best individual WR-CB matchup of the weekend. You have to play one of the best wideouts in the NFL when he has such a desirable individual matchup.
DeAndre Hopkins, Houston Texans
Hopkins is second among wideouts in targets (60), receptions (35), and touchdowns (5) — and he’s first in PPR fantasy points (101). Hopkins is seventh among all wideouts in fantasy points per opportunity.
Chris Hogan, New England Patriots
All Hogan does is score touchdowns. He’s tied with Hopkins for second-most scores (5) among wideouts through five weeks. Rob Gronkowski will return from action this week, so Hogan may not see 11 targets again, but he’s still a lock for 5-7 catches, 60-plus yards and a better-than-50-percent chance of scoring.
Landry the target hog will get even more looks in Week 6 with DeVante Parker doubtful to play. Landry’s Dolphins are massive 12.5-point road underdogs, which means plenty of garbage-time points. Landry also has a favorable matchup against Atlanta slot man Brian Poole, who has allowed 70 percent of passes thrown his way to be caught.
Am I crazy? Maybe. But Lewis looks like Cleveland’s only capable receiver, and he has two straight weeks with at least five catches and 60 yards, plus he’s extremely cheap. He’s not a lock to smash, but he’s a lock to return value.
Rob Gronkowski, New England Patriots
Gronkowski returns to the field after missing one week to face a Jets squad that he traditionally dominates. Excluding his rookie season and last year when he left early with an injury, Gronk has piled up 83 targets, 52 catches, 629 yards, and six scores against the Jets in just eight games.
Travis Kelce, Kansas City Chiefs
Assuming Kelce plays, he’s arguably the best bet at the position to top 100 yards, a feat he has already accomplished twice this year. He would have three 100-yard games if he didn’t get hurt in the Week 5 tilt.
Miller had a bankable seven targets in rookie quarterback Mitch Trubisky’s first start, and he should be peppered with looks again in Week 6 against a Ravens squad that has given up some massive games to tight ends this year.
Brate continues to be one of the NFL’s most reliable red-zone threats, and that will usually make him a solid DFS play. The Cardinals are traditionally strong against tight ends, but they were exposed last week by Philadelphia’s tight ends to the tune of 9-82-2. They also gave up a 9-99-0 line to Colts tight ends earlier in the year.
The Patriots have given up the fourth-most fantasy points to tight ends so far this year, and Seferian-Jenkins is New York’s best red-zone threat. He had some designed red-zone plays for him in Week 5, and that will surely be the case again in Week 6. The Pats have given up at least one score to tight ends in four of five games this year.