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Best and worst DFS targets in Week 16

Jacksonville, Florida, USA; Jacksonville Jaguars running back James Robinson (25) runs with the ball during the first half against the Houston Texans at TIAA Bank Field. Mandatory Credit: Matt Pendleton-USA TODAY Sports

Week 16 of the NFL DFS slate features a sure-fire RB1 week from Jacksonville Jaguars running back James Robinson and a developing rookie in Amon-Ra St. Brown, who has entered must-start territory.

Let’s dive into the best and worst Week 16 DFS plays at every position, based on matchup, opportunity, salary and roster projections.

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Best: Matthew Stafford, Los Angeles Rams
DK: $6,700 | FD: $7,900

After a tumultuous November, Stafford and the Rams have turned their fortune around, riding a three-game winning streak into Week 16. The veteran quarterback topped 22 fantasy points in three of his past four games, with his worst performance clocking in at 15.5 points this past week.

This week presents an excellent opportunity against a Minnesota Vikings defense that ranks 30th league-wide in passing yards allowed, 26th in passing touchdowns allowed and 27th in explosive pass percentage allowed.

Worst: Tom Brady, Tampa Bay Buccaneers
DK: $7,400 | FD: $8,400

Betting against the best player in NFL history seems like a mindless thing to do, and it might be. However, Brady has a tough matchup against the Carolina Panthers this weekend; he scored fewer than six fantasy points last week and now goes against one of the best-performing defenses in football without Chris Godwin and likely without Leonard Fournette and Mike Evans.

Brady has an exorbitant price tag. He is the third-most-expensive quarterback on the slate, according to FanDuel. I’d suggest paying down at the position or paying up for a different option. 

Carolina Panthers defense vs. quarterbacks | 2021
Category Number (Rank)
Passing yards allowed 2,779 (2nd)
Passing touchdowns allowed 21 (15th)
Explosive pass percentage allowed 13.0% (11th)
EPA per play against -0.122 (4th)
Fantasy points per game allowed 15.6 (5th)

Running Back

Best: James Robinson, Jacksonville Jaguars
DK: $5,900 | FD: $8,200

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