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NFL Week 6 Odds and Best Bets

Paradise, Nevada, USA; Los Angeles Chargers quarterback Justin Herbert (10) against the Las Vegas Raiders at Allegiant Stadium. Mandatory Credit: Mark J. Rebilas-USA TODAY Sports

Week 6 NFL odds are live, and the best time to bet them is now — before the lines move. We went 3-2 in Week 5 with one play left to go on Monday Night Football.

Equally as important, we saw closing line value (the line we bet in this article is better than the closing line with respect to the side we bet) on all our early bets except for the San Francisco 49ers, who ended up losing tight end George Kittle and didn't cover either the opening or closing lines.

Related content for you: Why betting early is critical to beating NFL markets via Robert Greer

We’re on to Week 6, which has a number of intriguing options based on early betting odds. All our initial reactions and guessing of the lines can be found on the PFF Forecast, which airs LIVE directly after Sunday Night Football and again Wednesday evening.

Click here for more PFF tools:

Rankings & ProjectionsWR/CB Matchup ChartNFL & NCAA Betting DashboardsNFL Player Props toolNFL & NCAA Power Rankings

Week 6 NFL Football Betting Odds (spread, total)

Find all current spreads and PFF’s model predictions on our NFL scores page

Bye: 49ers, Jets, Saints, Falcons

Thursday Night Football

Tampa Bay Buccaneers @ Philadelphia Eagles (+7, 52.5)

Sunday 1PM ET

Miami Dolphins vs. Jacksonville Jaguars (+3, 45) — in London 9:30 a.m. ET

Los Angeles Chargers @ Baltimore Ravens (-3.5, 50.5)

Minnesota Vikings @ Carolina Panthers (-1.5, 47.5)

Green Bay Packers @ Chicago Bears (+4.5, 46)

Cincinnati Bengals @ Detroit Lions (+3.5, 48.5)

Houston Texans @ Indianapolis Colts (-10.5, 43.5)

Los Angeles Rams @ New York Giants (+10.5, 47.5)

Kansas City Chiefs @ Washington Football Team (+6.5, 54.5)

Sunday 4PM ET

Arizona Cardinals @ Cleveland Browns (-2.5, 53.5)

Las Vegas Raiders @ Denver Broncos (-3, 44.5)

Dallas Cowboys @ New England Patriots (+3.5, 48)

Sunday Night Football

Seattle Seahawks @ Pittsburgh Steelers (-4, 42.5)

Monday Night Football

Buffalo Bills @ Tennessee Titans (+4.5, 53.5)

Week 6 Best Early NFL Bets

Tampa Bay Buccaneers (-7) @ Philadelphia Eagles

Point (George Chahrouri): Justin Herbert is getting all the MVP love, and deservedly so, but the highest-graded quarterback this year is Tom Brady — and for good reason. The GOAT has 18 big-time throws (PFF’s highest-graded set of passes) and zero turnover-worthy plays, ranking second and first, respectively. More importantly, all the Bucs wide receivers are now healthy, as evidenced by Mike Evans and Antonio Brown both catching two touchdowns in Week 5.

The Eagles have only one player in the secondary with a top-35 grade at their position (Darius Slay), including a particularly weak interior that Brady will dice up. The Bucs also have the athletes on defense to keep Jalen Hurts from beating them with his legs (see: Devin White).

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