Joseph Bryan's "Coach, I Was Open" model deducts which players could receive more targets in Week 6, including Travis Kelce.

Using route-level PFF data and the Predicted Targets Model, these players could be in line for large fantasy performances in Week 6.

As we near the midway point of the 2025 college football season, the Heisman Trophy race is heating up.

Rookies Cam Skattebo and Jaxson Dart led the Giants to a 34-17 upset over the Eagles on Thursday night, combining for four touchdowns to hand the defending NFC champions their second straight loss.

Cam Skattebo continues to solidify his role as the Giants' lead back, handling short-yardage, goal-line, and early-down work in a rotation that now mirrors Brian Daboll’s preferred backfield split.

Warren's production is on par with that of Brock Bowers and other elite tight end prospects from the last few years.

At PFF, the run game matters just as much as the pass game, and every play is meticulously graded. Each week, we’ll be looking at the highest-graded run blockers and run defenders from each position.

Injuries, weather, and public pick releases are just a few factors that can swing numbers. But spotting early signals—before prices settle into full efficiency—is where betting edges are made. Below, we’ll walk through how notable market-maker openers have shifted since Sunday and what those moves might be telling us.

Across 209 non-anytime-touchdown bets with an edge of 10% or higher, the tool delivered a 57.9% hit rate (121-88) and netted 17.9 units of profit in Week 5.

Cam Skattebo’s role in the Giants’ offense continues to grow, especially with key injuries thinning the receiving corps. He’s coming off another strong performance as a pass-catcher and ranks third among running backs in PFF receiving grade this season. Even with Tyrone Tracy returning, Skattebo should remain heavily involved in the passing game this week.

PFF’s media research team has been hard at work this week, preparing for kickoff — pulling data-driven insights and talking points for our broadcast partners around the league. Now, we’re sharing those same nuggets with you. So, whether you’re looking to win your fantasy matchup, hit on your bets or just get smarter about the game, these are the key storylines to know for every Week 6 contest.

Advanced coverage grade uses machine learning to map the separation allowed on a play to the expected PFF coverage grade the player would have earned had they been targeted. This system also takes into account the difficulty of the assignment and the situation when making that assessment.

This season, we will closely monitor NFL defensive line play throughout the season. Unlike our offensive line rankings, which in some cases consider previous-season rankings, these rankings will be based purely on 2025 play.

Each week, after every NFL game is graded and reviewed, PFF will check in on the top cornerbacks of the 2025 season. These rankings will change drastically over the first month, as one interception, one missed tackle, or one deep completion can significantly alter a player's grade when the sample size is small. But as snap counts rise, the grades will stabilize and we'll get a clearer picture of the league's best cornerbacks. 

Wondering how to handle Derrick Henry or Mason Taylor in Week 6 fantasy football lineups? Nathan Jahnke's start-sit column has you covered.

Michelle Magdziuk provides the top running back takeaways from Week 5 that could have a significant impact on fantasy football points in Week 6 and beyond.

Max Chadwick and Dalton Wasserman break down the biggest games of the Week 7 college football slate.

PFF is grading every player on every play during the 2025 NFL season, and these are the top wide receivers by PFF receiving grade through five weeks.