Sunday Night Football Week 6: Giants-Bills betting preview (odds, lines, best bets)

2RYK2TX Buffalo Bills quarterback Josh Allen (17) scrambles during an NFL football game, Sunday, Oct. 1, 2023, in Orchard Park, NY. (AP Photo/Matt Durisko)

• Bet Josh Allen OVER 2.5 passing touchdowns: The Bills pass at a top-five rate on early downs in the first half in neutral situations, while the Giants are giving up 15-plus-yard plays at the fourth-highest rate in the league.

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The New York Giants are in all sorts of trouble. They are down starting quarterback Daniel Jones after he picked up a neck injury last week, meaning backup Tyrod Taylor will get the start behind a makeshift offensive line.

New York starting left tackle Andrew Thomas is still not ready to return after already missing multiple weeks with a hamstring injury, so Joshua Ezeudu will continue to play. He has recorded PFF pass-blocking grades of 11.7 and 25.4 in the past three weeks. Right tackle Evan Neal has been bitterly disappointing since being drafted seventh overall, but he is also questionable with an ankle injury. His backup, Matt Peart, is already ruled out with a shoulder injury.

Giants running back Saquon Barkley remains questionable with an ankle injury that kept him out last week, and now tight end Darren Waller is questionable after being limited in practice all week. And three of the Giants' cornerbacks — Deonte Banks, Cordale Flott and Adoree' Jackson — are nursing their own injuries that limited them throughout the week before putting in full practices to close the week.

Buffalo has a couple of offensive injury concerns, as well. Tight ends Dalton Kincaid and Dawson Knox are questionable but relatively healthy for a game in which they will want to make a statement. They looked fairly lackluster for most of their Week 5 London game against the Jaguars despite quarterback Josh Allen throwing for 350 yards and Stefon Diggs and Gabe Davis each posting 100 receiving yards.


Josh Allen Over 2.5 Passing TDs (+250 FanDuel)

Buffalo is no stranger to running it up on teams this year, having already won three of five games by 28 points or more. The Bills will want to put a number on the board after stumbling their way through the game in London. Travel may have impacted their performance that day due to leaving for London on that Friday for an early kickoff, but there will be no such excuses this week.

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The Bills pass at a top-five rate on early downs in the first half in neutral situations, while the Giants are giving up 15-plus-yard plays at the fourth-highest rate in the league and allowing the third-most yards per coverage snap. Josh Allen has had three-plus passing touchdowns in nine of his past 23 games, including two of five this year. He has an almost perfect matchup and added motivation to do so again.

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