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Best NFL Week 7 Sunday Night Football single-game & player props bets

Indianapolis, Indiana, USA; Indianapolis Colts running back Jonathan Taylor (28) runs the ball into the end zone for a touchdown during the second half against the Houston Texans at Lucas Oil Stadium. The Colts win 31-3. Mandatory Credit: Marc Lebryk-USA TODAY Sports

Island games are the highlight of any NFL week for betting enthusiasts. As the industry continues to grow, some of the most discussed moments belong to single-game opportunities.

As such, below is the only betting guide needed to unearth tons of expected value for each Sunday night contest throughout the 2021 NFL regular season. After a perfect Thursday Night Football matchup, our overall record improved to 52-55, and with plus price options, we are up +10.76 units.

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Rankings & Projections | WR/CB Matchup Chart | NFL & NCAA Betting Dashboards | NFL Player Props tool | NFL & NCAA Power Rankings

Leverage PFF's predictive betting models and player props tools to identify the best betting opportunities in the Indianapolis ColtsSan Francisco 49ers Week 7 Sunday Night Football matchup.

Related content for you: NFL Week 7 Odds and Best Bets via Eric Eager and George Chahrouri


PFF Greenline uses exclusive game and player data to make projections on NFL game spreads, moneyline, and over/under.

It’s been a roller coaster of a week leading up to Sunday Night Football for all the reasons you never want to see – injuries.

The spread opened with the 49ers as five-point home favorites, but between injuries to QB Trey Lance, TE George Kittle, CB Jason Verrett and others, sportsbooks have given a point back to the Colts, who are coming off a dominant 31-3 shellacking of the Houston Texans.

Even after gaining the extra point, PFF Greenline still sees value in betting on the Colts — both via the +4 and the underdog moneyline.

The two matchups in this game that favor the Colts and will play a massive role in Indianapolis covering the four-point underdog spread are their defensive line versus the 49ers offensive line, which will likely be without Trent Williams, and their emerging wide receivers against San Francisco's secondary.

Williams is listed as doubtful for Sunday night’s game with an ankle injury, meaning the 49ers will likely be without their All-Pro tackle protecting Jimmy Garoppolo’s blindside, which will be a massive issue for Kyle Shanahan's offense given that Garoppolo ranks second to last among all QBs in passing grade under pressure (28.7).

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