Osa Odighizuwa is an interior defensive lineman for the San Francisco 49ers who earned a 46.9 overall PFF defensive grade in the 2026 season, 111th among 128 qualified interior defensive linemans. His PFF pass-rush grade of 63.2 ranked 58th among 128 qualified interior defensive linemans. His run-defense grade of 38.5 ranked 114th at the position.
He generated 21 total pressures as a pass rusher. That total included 2 sacks, 14 hurries, 5 hits. Against the run, he recorded 6 solo tackles.