- Julian Sayin was nearly as efficient as possible: The Ohio State signal-caller threw more touchdowns than incompletions in the No. 1 Buckeyes' win over Penn State.
- Colin Simmons was elite in Texas‘ upset win: The edge defender logged a season-high seven pressures against Vanderbilt en route to a 91.3 PFF pass-rush grade.
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CLICK HERE TO SEE COLLEGE FOOTBALL GRADES FOR WEEK 10
Highest-graded players: Offense (non-quarterbacks)
| Name | Team | Pos. | Snaps | PFF Grade |
| Shelton Samspon Jr. | La. Lafayette | WR | 46 | 94.3 |
| Donte Lee Jr. | Liberty | WR | 36 | 94.2 |
| Evan Dickens | Liberty | HB | 39 | 94.1 |
| Jacob Jenkins | Liberty | TE | 32 | 93.7 |
| Elijah Green | Sam Houston | HB | 22 | 93.0 |
| David Amador II | UTSA | WR | 43 | 92.3 |
| Cameron Miller | Kentucky | WR | 25 | 91.7 |
| Jeremiah Smith | Ohio State | WR | 43 | 90.1 |
| Duce Robinson | Florida State | WR | 49 | 90.1 |
| Eli Finley | LA Tech | TE | 48 | 89.6 |
Highest-graded defenders
| Name | Team | Pos. | Snaps | PFF Grade |
| Avarion Cole | Western Kentucky | S | 43 | 92.9 |
| Eddrick Houston | Ohio State | Dl | 20 | 92.5 |
| Quandarius Keyes | UNLV | CB | 22 | 92.3 |
| Colin Simmons | Texas | EDGE | 44 | 92.1 |
| Kam Robinson | Virginia | LB | 51 | 91.9 |
| Austin Romaine | Kansas State | LB | 64 | 91.8 |
| Jacob Rodriguez | Texas Tech | LB | 62 | 91.7 |
| Shawn Lee Jr. | Pittsburgh | CB | 41 | 91.5 |
| Kyle Louis | Pittsburgh | LB | 62 | 91.4 |
| Qwyn Williams | Hawaii | Dl | 26 | 91.3 |
Highest-graded quarterbacks
| Name | Team | Snaps | PFF Grade |
| Lunch Winfield | La. Lafayette | 63 | 92.5 |
| Julian Sayin | Ohio State | 57 | 92.2 |
| Owen McCown | UTSA | 72 | 92 |
| Katin Houser | East Carolina | 65 | 91.9 |
| Alberto Mendoza | Indiana | 14 | 91.6 |
| Nick Minicucci | Delaware | 75 | 91.3 |
| Tommy Castellanos | Florida State | 49 | 91.1 |
| Landon Sims | Wyoming | 10 | 90.8 |
| Kevin Jennings | SMU | 71 | 90.0 |
| Ethan Vasko | Liberty | 53 | 89.2 |
Offensive Player and QB of the Week: QB Julian Sayin, Ohio State
Sayin threw for four touchdowns in Ohio State's win over Penn State — one more than his total number of incompletions in the game. He went 20-of-23 for 316 yards with a pair of big-time throws and no turnover-worthy plays on his way to a 91.7 PFF passing grade.
Defensive Player of the Week: LB Austin Romaine, Kansas State
Romaine was all over the field for Kansas State against Texas Tech this week, earning PFF grades above 80.0 as a run defender, a pass rusher and a coverage defender. He finished the game with nine tackles resulting in a defensive stop, three pressures and an interception.
Offensive Line of the Week: Florida
Despite the team's loss to Georgia this week, Florida’s offensive line had a solid day. Four of their five starting offensive linemen earned 67.5 PFF pass-blocking grades or better, and they combined to allow just two pressures from 31 pass-blocking snaps.
Quarterback of the Week: QB Julian Sayin, Ohio State
See above.
Run Defender of the Week: LB Tywon Christopher, Kennesaw State
Christopher put together one of the best performances against the run in college football this season. He earned a 96.4 PFF run-defense grade, registered seven tackles resulting in a defensive stop and forced a fumble.
Pass Rusher of the Week: EDGE Colin Simmons, Texas
Simmons logged a season-high seven pressures, including one sack, for Texas in a win over Vanderbilt. He posted a 43.4% PFF pass-rush win rate and forced a fumble en route to a 91.3 PFF pass-rush grade.
Coverage Defender of the Week: S Avarion Cole, Western Kentucky
Cole earned a 91.9 PFF coverage grade in Western Kentucky‘s win over New Mexico State. He finished the game with a tackle resulting in a defensive stop and allowed just one reception for eight yards, despite being targeted five times in coverage. He also notched an interception and a pair of pass breakups.