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Buffalo Bills at Carolina Panthers
| Spread | Total | Moneyline | |
| Buffalo Bills | +6.5 (-110) | O 39.5 (-110) | +200 |
| Carolina Panthers | -6.5 (-110) | U 39.5 (-110) | -250 |
Seattle Seahawks at Dallas Cowboys
| Spread | Total | Moneyline | |
| Seattle Seahawks | -7 (-110) | O 37.5 (-110) | -300 |
| Dallas Cowboys | +7 (-110) | U 37.5 (-110) | +240 |
Los Angeles Chargers at New Orleans Saints
| Spread | Total | Moneyline | |
| Los Angeles Chargers | +3 (-110) | O 36.5 (-110) | +135 |
| New Orleans Saints | -3 (-110) | U 36.5 (-110) | -165 |
New England Patriots at Las Vegas Raiders
| Spread | Total | Moneyline | |
| New England Patriots | +1.5 (-110) | O 37.5 (-110) | +100 |
| Las Vegas Raiders | -1.5 (-110) | U 37.5 (-110) | -120 |
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