PFF Bets of the Week: NFL Week 13

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Week 13 is here, and PFF’s analysts have locked in their favorite bets of the week, powered by the PFF Player Prop Tool.

The tool delivers real-time projections, matchup data, hit rates and the best available odds all in one place. It’s the same level of insight trusted by all 32 NFL teams, now at your fingertips.

Here are our analysts' favorite bets for the Week 13 Sunday slate.

Trevor Sikkema (7-5)

QB Drake Maye, New England Patriots: Over 4.5 carries (-155 BetMGM)

Maye’s 4.5 line stands out immediately. He’s topped 10 rushing yards in 10 straight games, and now gets a Giants defense ranked dead last in PFF run-defense grade — plus any late-game kneel-downs only boost the carry count.

Dalton Wasserman (7-5)

RB TreVeyon Henderson, New England Patriots: Over 14.5 carries (-130 BetMGM)

Henderson has logged at least 14 carries in four straight games, and even with Rhamondre Stevenson returning in Week 12, he still handled 18 attempts to Stevenson’s six. With the Giants now ranking dead last in PFF run-defense grade, the Patriots should lean heavily on the ground game — and Henderson projects to be the clear lead back who benefits most.

Ben Linsey (9-3)

Travis Etienne Jr., Jacksonville Jaguars: Over 57.5 rushing yards (-115 BetMGM)

The Jaguars have run the ball at a top-five rate leaguewide since their Week 8 bye. Even removing their blowout win over the Chargers, they still rank inside the top 10 in their other three competitive games. And despite some discussion about a more even split between Travis Etienne and Bhayshul Tuten entering Week 12, Etienne handled 15 carries for 86 yards compared to Tuten’s seven carries for 17 yards.

Now Etienne gets a Titans defense that ranks 26th in yards allowed per carry on designed runs, and with Jacksonville favored by 6-plus, the game script sets up squarely in his favor.

Mason Cameron (4-7-1)

WR Khalil Shakir, Buffalo Bills: Over 4.5 receptions (-110)

Shakir has been on a tear, stacking six or more catches in four of his past five games. He gets another favorable draw this week against a Steelers defense that has struggled to contain receivers, giving up the most receptions in the NFL to the position. He’ll again see a plus matchup in the slot against Brandin Echols, who has allowed an average of 5.25 receptions per game since taking over as the Steelers' primary slot cornerback in Week 9.

With Dalton Kincaid’s Week 13 status still uncertain, Shakir should remain positioned to thrive as the top target in this Bills offense.

Max Chadwick (4-6-2)

QB Shedeur Sanders, Cleveland Browns: Over 14.5 completions (-114 FanDuel)

Sanders will make the second start of his career this week against the San Francisco 49ers. The Browns are 5.5-point underdogs, which could lead to a heavier passing script than his first start against the Raiders.

Sanders completed only 11 passes in Week 12, but he attempted just 20 because Cleveland held a two-score lead from late in the first quarter through the end of the game. The 49ers rank 27th in pass-rush grade and 23rd in coverage grade, so Sanders could find success against their defense.

Gordon McGuinness (4-7-1)

QB Marcus Mariota, Washington Commanders: Under 1.5 passing TDs (-250 Bet MGM)

The Broncos defense has been a tough unit to face for any offense this season, with only two quarterbacks clearing this mark against them through 12 weeks. Mariota has been solid in relief of starting quarterback Jayden Daniels but has thrown multiple touchdowns in just two of his five starts.