NFL Week 10 Betting: Prop bets to target

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These are some of the best player prop bets to target in Week 10 for the 2025 NFL season.

QB Caleb Williams, Chicago Bears: Over 4.5 rushing attempts (+106)

This line has moved higher since PFF lead draft analyst Trevor Sikkema highlighted it on our Best Bets of Week 10 write-up. The logic here is still sound — and there's even more value at plus-money. With inclement weather also forecasted in Chicago, this will be another game where Caleb Williams can flourish with his legs.

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The young signal-caller has surpassed this line in five of his nine matchups this season, and he now faces a New York Giants defense that has struggled with mobile quarterbacks. New York’s defense has faced five or more quarterback rushing attempts in all but two games this season. That’s due in large part to their high rate of man coverage, which generally opens up scramble opportunities.

The Bears are also favored in this game, and the Giants‘ offense has struggled significantly without many weapons. There may be opportunities for kneel-downs to add to the Williams rushing totals, evidenced by the fact that the Giants have faced the fourth-most kneel-downs in the NFL.

WR Emeka Egbuka, Tampa Bay Buccaneers: Over 5.5 receptions (+115)

Coming out of the Buccaneers’ Week 9 bye, Emeka Egbuka has had ample rest for the hamstring injury that put his status in doubt the week prior. Unfortunately, the same can’t be said for other key Tampa Bay weapons, Chris Godwin and Bucky Irving, who are again ruled out. That will thrust the rookie into the spotlight once more. Without Godwin, Irving and Mike Evans — who was lost for the year — on the field, Egbuka has been far and away the Buccaneers’ top pass-catcher, with his 28.0% target rate per route run standing as a team-best mark by a wide margin.

Baker Mayfield and the Tampa Bay offense will need to rely on Egbuka in their Week 10 matchup, given the New England Patriots‘ defensive profile. The Patriots are particularly stout against the run, allowing the fifth-lowest rushing success rate (25.7%), which has nudged opposing offenses to the passing game (67.0%). And without Irving, the Buccaneers generate just 3.4 yards per carry on average (30th).

Egbuka’s talents will be on full display against a Patriots coverage unit that has struggled to match receivers, ranking just 24th in PFF coverage grade (36.8) against the position. New England has surrendered some impressive performances to receivers this season, including a nine-catch outing for Drake London this past week that generated 118 yards and three touchdowns.