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NFL Betting 2022: Wild-card round spread picks to bet before lines move

Santa Clara, California, USA; San Francisco 49ers quarterback Brock Purdy (13) runs the ball against the Arizona Cardinals in the third quarter at Levi's Stadium. Mandatory Credit: Cary Edmondson-USA TODAY Sports

• Bet the over in Seahawks-49ers: The number is just 43.5 for this game, which seems notably low for a San Francisco squad averaging 33.5 points per game since Brock Purdy took over as their starting quarterback.

• Take the Chargers (-1.5) against the Jaguars: Picking a side in this game ultimately comes down to who the better quarterback is, and Justin Herbert takes the win there.

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Estimated Reading Time: 6 mins

Editor's Note: Betting lines are accurate as of post-Sunday Night Football.

Seattle Seahawks @ San Francisco 49ers over 43.5

Why to bet:

Yes, this number is for both teams combined. Yes, this is a giant slap in the face to Brock Purdy. The 49ers are averaging 33.5 points per game in their past six games since the rookie took over as the starting quarterback. The 49ers also have the third-best expected points added per play mark in the NFL over that span. The Seahawks rank just 25th in expected points allowed per run play.

The Seahawks finally have a healthy Tyler Lockett back, which will be massive against a 49ers defense that, while very good, has a few defensive backs who can be had. In a game where the 49ers are 9.5-point favorites, the Seahawks will likely have to throw to stay in this one, making the over a lovely bet.

Why to be wary:

If there is reason to worry, it would be that both teams have enough success running the ball that they never throw and the game grinds along. That said, the 49ers rank second in the NFL in expected points allowed per run play, which should force the Seahawks to pass.


Los Angeles Chargers (-1.5) @ Jacksonville Jaguars

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