Fantasy Football: 3 WR/CB matchups to target and avoid for Week 6

Xavier Worthy could feast against an injured Lions secondary: The Chiefs receiver should get an advantageous matchup against Amik Robertson on Sunday night.

Darnell Mooney could struggle against Tre'Davious White: The Falcons receiver has yet to truly get going, and faces a defense that's permitted the seventh-fewest receiving yards to wide receivers in 2025.

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Estimated Reading Time: 12 minutes

Identifying advantageous and disadvantageous cornerback matchups is a critical facet of fantasy football’s lineup-setting process. This article details six wide receivers’ positive and negative environmental factors, with particular attention paid to their primary coverage foe, resulting in three recommended matchups to target and three to avoid for Week 6.

WR/CB Matchups to Target

WR Tetairoa McMillan, Carolina Panthers vs. CB Trevon Diggs, Dallas Cowboys

Carolina Panthers rookie No. 1 wide receiver Tetairoa McMillan boasts four WR3 finishes and one WR4 finish in five career games. He can be treated as a Week 6 WR2 candidate against the Dallas Cowboys. He has strong odds of scoring his first career touchdown, and McMillan’s matchup against the Cowboys’ No. 1 perimeter cornerback, Trevon Diggs, and 11 personnel perimeter cornerback, Kai ir Elam, increases his fantasy-scoring ceiling.