NFL Week 6: PrizePicks best prop bets

• Available exclusively to PFF+ subscribers in the PFF app, the PFF Player Prop Tool harnesses the power of predictive analytics and matchup data to help you make smarter, faster and more confident picks. Download the PFF app now — available on the Apple App Store and Google Play Store.

Each week, we will analyze some of the best player statistics on PrizePicks with the help of the new PFF Player Props Tool. Betting insights, matchup data and historical hit rates are just a few of the things the tool offers.

Here are two props that stand out ahead of Week 6 of the 2025 NFL season.

RB Jahmyr Gibbs, Detroit Lions: More than 24.5 receiving yards

Gibbs ranks among the top three running backs in both targets (23) and receptions (22) through the first five weeks of the season. This week, Detroit travels to Kansas City for a Sunday night showdown with the Chiefs. On paper, it looks like the game of the week.

The Chiefs’ defense allowed a high rate of running back targets, ranking 30th in that category this season. This game has the league’s highest point total for Week 6, currently sitting at an over/under of 53 points. 

Gibbs has recorded at least 30 receiving yards in three of five games this season, with the two others coming in blowout Lions victories: Week 2 against the Bears (52-21) and Week 4 against the Browns (34-10). The Lions are currently 2.5-point underdogs on the road and will likely be forced to utilize Gibbs through the air, so I am targeting his 24.5-receiving-yard prop.

WR Xavier Worthy, Kansas City Chiefs: More than 4.5 receptions

I’m sticking with the Lions-Chiefs matchup, highlighting wide receiver Xavier Worthy and his receptions prop. Worthy has been targeted 18 times over the past two weeks since he returned from a shoulder injury suffered in Week 1 and is coming off a six-reception game against the Jaguars.

Dating back to last season, Worthy has caught at least five passes in each of the past 10 games (excluding Week 1 against the Chargers, when he left injured). He has established himself as Patrick Mahomes’ go-to weapon, at least for one more game before Rashee Rice returns from suspension.

Also working in Worthy’s favor is a matchup with Detroit’s beat-up secondary. The Lions lost starting cornerback Terrion Arnold indefinitely after he suffered a shoulder injury last week and placed their other starting cornerback, D.J. Reed, on injured reserve last week due to a hamstring injury. The injuries leave Detroit vulnerable in the secondary, something the Chiefs figure to attack early and often in Week 6.