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Buffalo Bills @ Indianapolis Colts – CBS, 1:00 PM
Pass-catchers need to step up
The Bills wide receiving corps has done their offense no favors this year. They've combined for just 2.39 yards per route run and a 75.0% catch rate – which are both the worst marks in the league. 
McCoy off to a slow start
LeSean McCoy is averaging just 1.95 yards after contact per attempt this year, which is the lowest mark qualifying among running backs. With veteran quarterback Derek Anderson set to start at quarterback for the Bills on Sunday, the team need the running game to step up and take the pressure off.
White still going strong
Tre'Davious White has been a bright spot on the Bills' defense this season. Through six weeks, he's forced an incompletion on 28.6% of his targets, which is the third-best rate in the league.
Edmunds biting on the play fake
First-round rookie Tremaine Edmunds has allowed a passer rating of 141.7 on play-action passes into his coverage. He'll need to keep his wits about him on Sunday against the Colts.
Luck in the end zone
Andrew Luck has been one of the most successful signal-callers in the league when it comes to targeting the end zone. He'll look to continue his strong start against a talented Bills defense.
Hines getting to the sticks
Running back Nyheim Hines has been targeted 37 times so far this season, and he's produced 15 first downs on those targets, which is tied for the second-most by a running back this year. The Bills better watch out for him on Sunday.
Sheard rushing from the left
Edge defender Jabaal Sheard has racked up 22 total quarterback pressures from the left side, the fourth-most among edge defenders. It will be fascinating to see how he gets on against Bills' right tackle Jordan Mills.
Leonard making all the stops
Rookie linebacker Darius Leonard has made plays against the run and the pass this year. He's one of only four defensive players with at least 10 stops in both facets.
Key matchup
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