NFL Week 6 Betting: Prop bets to target

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These are some of the best player prop bets to target in Week 6 for the 2025 NFL season.

QB Dak Prescott, Dallas Cowboys: Over 240.5 passing yards (-115)

Prescott has been dealing and steadily climbing the leaderboard for Comeback Player of the Year. His 88.8 PFF passing grade (fourth), 1,356 passing yards (second) and 14 big-time throws (third) all rank inside the top five in the NFL this season. Amid the extended absence of wide receiver CeeDee Lamb, Prescott has elevated the play of anyone and everyone on the receiving depth chart. 

This week, the Cowboys' passing game is in a plus matchup against a Carolina Panthers defense that ranks 22nd in PFF coverage grade (54.4), largely because of difficulties in limiting explosive plays. Prescott is lethal down the field, having recorded the fourth-highest percentage of accurate throws targeted 15 or more yards downfield (54.5%). 

The Cowboys’ signal-caller is poised for another big performance this week against the Panthers’ zone-heavy defense. Carolina runs the fourth-highest rate of zone coverage in the NFL, which doesn’t bode well for them against Prescott, who picks apart zone looks. He has produced the highest EPA per pass against zone this season.

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QB Joe Flacco, Cincinnati Bengals: Under 218.5 passing yards (-118)

With Joe Flacco set to take over at quarterback for Jake Browning, bettors may be tempted to take an optimistic approach toward the Bengals' offense.

Don’t.

The veteran quarterback will have just five days to learn the offense, which will likely lead to a limited playbook. To make matters worse, the Bengals head to Green Bay to take on one of the strongest defenses in the NFL (79.0 team PFF defense grade; fourth). Micah Parsons headlines a potent Packers pass rush that has generated pressure at the fifth-highest rate (42.5%) in the NFL. Flacco ranks just 31st out of 38 qualifying quarterbacks in PFF overall grade under pressure (46.4) — below that of even the quarterback he’s replacing. Cincinnati (44.0) places just one spot ahead of Cleveland (39.9) in team PFF pass-blocking grade, with both falling in the bottom five in the NFL.

Flacco has the added disadvantage of having been battered by this same Packers defense just three weeks ago. In that Week 3 matchup, he was pressured on more than 45% of his dropbacks and knocked down 12 times, on his way to totaling just 142 passing yards.